T Cell Activation by Coxsackievirus B4 Antigens in Type 1 Diabetes Mellitus: Evidence for Selective TCR Vβ Usage Without Superantigenic Activity

^*Department of Immunology, Guy’s, King’s and St. Thomas’ School of Medicine, London, United Kingdom;
^†Rheumatology Unit, Institute of Child Health, UCL, London, United Kingdom; and
^‡Division of Medicine, University of Bristol, Bristol, United Kingdom

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Article usage

Article usage: September 2001 to January 2021

	Abstract	Full	Pdf
Sep 2001	102	97	103
Oct 2001	76	50	34
Nov 2001	9	20	22
Dec 2001	5	24	24
Total 2001	192	191	183
Jan 2002	6	35	28
Feb 2002	2	13	14
Mar 2002	0	20	11
Apr 2002	4	13	6
May 2002	6	13	7
Jun 2002	1	7	6
Jul 2002	2	7	11
Aug 2002	1	13	4
Sep 2002	6	12	8
Oct 2002	0	8	3
Nov 2002	1	14	15
Dec 2002	1	8	7
Total 2002	30	163	120
Jan 2003	4	11	12
Feb 2003	4	12	13
Mar 2003	1	3	5
Apr 2003	0	10	4
May 2003	6	6	6
Jun 2003	0	5	6
Jul 2003	4	7	8
Aug 2003	8	18	5
Sep 2003	13	14	4
Oct 2003	9	9	4
Nov 2003	9	18	3
Dec 2003	8	16	0
Total 2003	66	129	70
Jan 2004	13	19	9
Feb 2004	9	12	9
Mar 2004	6	16	6
Apr 2004	18	20	7
May 2004	38	42	9
Jun 2004	58	47	6
Jul 2004	42	43	6
Aug 2004	62	51	4
Sep 2004	26	25	2
Oct 2004	16	26	3
Nov 2004	30	25	12
Dec 2004	9	41	17
Total 2004	327	367	90
Jan 2005	4	17	4
Feb 2005	28	13	8
Mar 2005	13	41	13
Apr 2005	2	13	6
May 2005	3	11	4
Jun 2005	5	15	4
Jul 2005	13	7	5
Aug 2005	7	4	0
Sep 2005	5	16	6
Oct 2005	2	18	8
Nov 2005	3	18	11
Dec 2005	9	12	0
Total 2005	94	185	69
Jan 2006	3	15	4
Feb 2006	6	22	9
Mar 2006	3	14	4
Apr 2006	1	21	6
May 2006	1	9	6
Jun 2006	1	16	2
Jul 2006	0	6	0
Aug 2006	1	7	3
Sep 2006	1	13	6
Oct 2006	13	17	4
Nov 2006	9	18	0
Dec 2006	0	9	1
Total 2006	39	167	45
Jan 2007	3	13	6
Feb 2007	2	7	5
Mar 2007	2	19	10
Apr 2007	2	14	6
May 2007	6	13	3
Jun 2007	3	8	3
Jul 2007	4	10	7
Aug 2007	1	5	1
Sep 2007	3	6	5
Oct 2007	0	8	4
Nov 2007	6	14	13
Dec 2007	11	14	2
Total 2007	43	131	65
Jan 2008	7	9	4
Feb 2008	9	5	5
Mar 2008	10	10	8
Apr 2008	15	2	4
May 2008	9	4	2
Jun 2008	9	15	11
Jul 2008	13	8	6
Aug 2008	19	12	2
Sep 2008	98	9	4
Oct 2008	106	9	8
Nov 2008	23	9	4
Dec 2008	5	6	1
Total 2008	323	98	59
Jan 2009	9	11	10
Feb 2009	9	12	3
Mar 2009	9	7	3
Apr 2009	14	7	7
May 2009	13	8	2
Jun 2009	11	8	2
Jul 2009	9	9	2
Aug 2009	16	8	9
Sep 2009	5	4	5
Oct 2009	9	10	7
Nov 2009	8	15	10
Dec 2009	9	8	5
Total 2009	121	107	65
Jan 2010	5	14	5
Feb 2010	11	3	5
Mar 2010	3	12	3
Apr 2010	5	8	5
May 2010	10	5	2
Jun 2010	5	6	4
Jul 2010	7	5	9
Aug 2010	5	3	3
Sep 2010	5	5	2
Oct 2010	19	5	2
Nov 2010	2	8	4
Dec 2010	2	6	7
Total 2010	79	80	51
Jan 2011	4	2	2
Feb 2011	1	2	6
Mar 2011	7	5	5
Apr 2011	2	9	4
May 2011	5	3	5
Jun 2011	4	10	3
Jul 2011	3	4	4
Aug 2011	8	5	3
Sep 2011	9	6	7
Oct 2011	8	9	7
Nov 2011	8	11	7
Dec 2011	3	8	6
Total 2011	62	74	59
Jan 2012	6	2	6
Feb 2012	5	3	4
Mar 2012	3	4	4
Apr 2012	4	10	7
May 2012	15	7	11
Jun 2012	8	9	10
Jul 2012	5	9	6
Aug 2012	3	5	2
Sep 2012	3	8	8
Oct 2012	4	5	9
Nov 2012	8	3	15
Dec 2012	7	8	6
Total 2012	71	73	88
Jan 2013	10	5	10
Feb 2013	2	7	5
Mar 2013	4	5	11
Apr 2013	8	14	4
May 2013	4	8	9
Jun 2013	3	6	11
Jul 2013	11	3	7
Aug 2013	3	4	9
Sep 2013	9	6	13
Oct 2013	5	3	9
Nov 2013	7	2	6
Dec 2013	7	2	5
Total 2013	73	65	99
Jan 2014	4	5	16
Feb 2014	0	2	6
Mar 2014	2	4	22
Apr 2014	2	5	4
May 2014	6	1	10
Jun 2014	2	5	8
Jul 2014	9	7	7
Aug 2014	6	0	4
Sep 2014	2	2	13
Oct 2014	2	3	10
Nov 2014	4	3	16
Dec 2014	5	1	13
Total 2014	44	38	129
Jan 2015	3	3	7
Feb 2015	4	0	7
Mar 2015	7	4	7
Apr 2015	2	1	3
May 2015	2	3	5
Jun 2015	7	4	4
Jul 2015	3	8	11
Aug 2015	1	8	4
Sep 2015	10	1	1
Oct 2015	1	3	5
Nov 2015	8	5	7
Dec 2015	8	5	9
Total 2015	56	45	70
Jan 2016	5	3	6
Feb 2016	0	2	6
Mar 2016	4	4	12
Apr 2016	5	5	7
May 2016	7	3	9
Jun 2016	6	6	2
Jul 2016	0	8	8
Aug 2016	2	3	3
Sep 2016	0	3	7
Oct 2016	7	1	6
Nov 2016	0	5	6
Dec 2016	3	1	5
Total 2016	39	44	77
Jan 2017	2	1	4
Feb 2017	0	21	6
Mar 2017	0	9	4
Apr 2017	3	5	3
May 2017	5	8	0
Jun 2017	2	6	0
Jul 2017	2	5	1
Aug 2017	0	2	1
Sep 2017	1	3	2
Oct 2017	3	2	0
Nov 2017	0	7	4
Dec 2017	1	2	8
Total 2017	19	71	33
Jan 2018	1	4	2
Feb 2018	5	4	1
Mar 2018	2	11	4
Apr 2018	1	3	1
May 2018	2	17	3
Jun 2018	3	6	0
Jul 2018	0	3	1
Aug 2018	0	2	2
Sep 2018	2	13	3
Oct 2018	8	3	2
Nov 2018	4	11	7
Dec 2018	0	12	0
Total 2018	28	89	26
Jan 2019	4	12	2
Feb 2019	2	9	2
Mar 2019	0	8	3
Apr 2019	6	8	4
May 2019	2	10	6
Jun 2019	7	14	2
Jul 2019	1	7	1
Aug 2019	5	34	11
Sep 2019	1	27	2
Oct 2019	6	40	4
Nov 2019	7	7	5
Dec 2019	1	10	5
Total 2019	42	186	47
Jan 2020	1	11	2
Feb 2020	4	11	11
Mar 2020	2	9	2
Apr 2020	1	11	3
May 2020	0	7	4
Jun 2020	0	4	0
Jul 2020	1	5	5
Aug 2020	0	19	1
Sep 2020	1	8	6
Oct 2020	1	5	4
Nov 2020	0	8	3
Dec 2020	2	3	0
Total 2020	13	101	41
Jan 2021	3	6	13
Total 2021	3	6	13
Total	1764	2410	1499