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About the Cover

October 1, 2000; Volume 165,Issue 7

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On the Cover: Model of the structure of Btk SH2 domain. A, A stereo view of the modeled structure of Btk SH2 domain. The analyzed XLA-causing mutations are shown on the left. On the right are amino acids predicted to be involved in the binding of pY-containing ligands. The peptide bound to the domain has sequence pYEEI. Residues recognizing and binding phosphotyrosine are colored with orange, and those binding to pY + 1 are in green. The hydrophobic pY + 3 binding pocket is in yellow. Y334, participating in both pY + 1 and pY + 3 binding, is in white. B, Binding of the pYEEI peptide to the Btk SH2 domain. Residues involved are colored as in A. The SH2 domain is shown with the surface presentation, and the peptide with a stick model. The binding residues are clearly visible. The peptide-SH2 domain interaction indicates structural complementarity. (Figure 1 from Mattsson, P. T., I. Lappalainen, C.-M. Backesjo, E. Brockmann, S. Lauren, M.Vihinen, and C. I. E. Smith. Six X-linked agammaglobulinemia-causing missense mutations in the Src homology a domain of Bruton's tyrosine kinase: phosphotyrosine-binding and circular dichroism analysis. J. Immunol. 164:4170.)

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The Journal of Immunology: 165 (7)
The Journal of Immunology
Vol. 165, Issue 7
1 Oct 2000
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  • CUTTING EDGE
  • CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • HOST DEFENSE
  • INFLAMMATION
  • CLINICAL IMMUNOLOGY
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Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection
Osteoclasts Derive Predominantly from Bone Marrow–Resident CX3CR1+ Precursor Cells in Homeostasis, whereas Circulating CX3CR1+ Cells Contribute to Osteoclast Development during Fracture Repair
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
Natural and Induced Tolerogenic Dendritic Cells
Cutting Edge: IL-6–Driven Immune Dysregulation Is Strictly Dependent on IL-6R α-Chain Expression

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Print ISSN 0022-1767        Online ISSN 1550-6606