Tetramer-Guided Analysis of TCR β-Chain Usage Reveals a Large Repertoire of Melan-A-Specific CD8+ T Cells in Melanoma Patients

^*Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital, and
^†Multidisciplinary Oncology Center, University Hospital, Lausanne, Switzerland;
^‡Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland;
^§Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom; and
^¶Laboratory of Tumor Immunology, Division of Oncology, University Hospital, Geneva, Switzerland

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Article usage

Article usage: September 2000 to March 2021

	Abstract	Full	Pdf
Sep 2000	2	8	1
Oct 2000	4	52	33
Nov 2000	10	43	19
Dec 2000	1	11	10
Total 2000	17	114	63
Jan 2001	4	38	23
Feb 2001	3	14	8
Mar 2001	0	13	12
Apr 2001	2	18	10
May 2001	0	12	9
Jun 2001	4	11	17
Jul 2001	0	10	29
Aug 2001	0	17	11
Sep 2001	3	18	15
Oct 2001	1	13	16
Nov 2001	1	9	7
Dec 2001	1	3	5
Total 2001	19	176	162
Jan 2002	1	12	9
Feb 2002	2	14	13
Mar 2002	1	14	14
Apr 2002	2	6	10
May 2002	0	12	16
Jun 2002	0	5	3
Jul 2002	3	11	9
Aug 2002	1	10	9
Sep 2002	1	10	8
Oct 2002	2	5	7
Nov 2002	1	5	13
Dec 2002	4	12	8
Total 2002	18	116	119
Jan 2003	2	8	8
Feb 2003	1	4	7
Mar 2003	0	10	8
Apr 2003	0	8	6
May 2003	3	15	7
Jun 2003	1	11	12
Jul 2003	2	7	5
Aug 2003	11	13	5
Sep 2003	13	12	4
Oct 2003	9	14	5
Nov 2003	12	13	5
Dec 2003	3	8	6
Total 2003	57	123	78
Jan 2004	9	17	8
Feb 2004	7	10	4
Mar 2004	9	15	11
Apr 2004	10	25	8
May 2004	7	14	10
Jun 2004	8	14	6
Jul 2004	6	18	10
Aug 2004	12	19	6
Sep 2004	7	20	2
Oct 2004	3	18	9
Nov 2004	6	13	4
Dec 2004	3	13	1
Total 2004	87	196	79
Jan 2005	5	22	2
Feb 2005	21	12	8
Mar 2005	5	13	6
Apr 2005	1	8	9
May 2005	2	10	4
Jun 2005	3	11	6
Jul 2005	3	10	3
Aug 2005	6	19	5
Sep 2005	4	10	4
Oct 2005	6	14	4
Nov 2005	4	10	0
Dec 2005	4	11	5
Total 2005	64	150	56
Jan 2006	4	2	3
Feb 2006	1	9	1
Mar 2006	6	18	5
Apr 2006	3	9	6
May 2006	1	5	3
Jun 2006	3	7	2
Jul 2006	6	10	5
Aug 2006	1	11	2
Sep 2006	7	7	3
Oct 2006	12	17	8
Nov 2006	6	15	8
Dec 2006	1	4	3
Total 2006	51	114	49
Jan 2007	1	10	5
Feb 2007	2	6	1
Mar 2007	3	21	10
Apr 2007	1	12	7
May 2007	6	11	2
Jun 2007	6	12	9
Jul 2007	6	13	8
Aug 2007	10	16	4
Sep 2007	9	15	6
Oct 2007	5	4	5
Nov 2007	4	4	10
Dec 2007	4	6	2
Total 2007	57	130	69
Jan 2008	6	9	5
Feb 2008	5	10	13
Mar 2008	10	17	9
Apr 2008	4	12	6
May 2008	14	3	4
Jun 2008	7	9	8
Jul 2008	15	8	3
Aug 2008	9	8	1
Sep 2008	56	3	1
Oct 2008	16	5	3
Nov 2008	13	7	5
Dec 2008	2	7	4
Total 2008	157	98	62
Jan 2009	3	4	2
Feb 2009	9	7	7
Mar 2009	8	9	7
Apr 2009	4	7	5
May 2009	4	7	1
Jun 2009	8	7	6
Jul 2009	7	6	1
Aug 2009	1	4	1
Sep 2009	6	6	3
Oct 2009	12	12	4
Nov 2009	10	3	4
Dec 2009	4	5	4
Total 2009	76	77	45
Jan 2010	2	6	4
Feb 2010	1	2	1
Mar 2010	5	6	6
Apr 2010	1	6	2
May 2010	3	6	6
Jun 2010	5	5	4
Jul 2010	5	14	12
Aug 2010	1	2	3
Sep 2010	2	2	1
Oct 2010	0	8	4
Nov 2010	0	6	2
Dec 2010	5	5	4
Total 2010	30	68	49
Jan 2011	4	10	7
Feb 2011	3	3	4
Mar 2011	5	6	2
Apr 2011	2	8	8
May 2011	4	9	4
Jun 2011	6	10	3
Jul 2011	0	3	4
Aug 2011	5	4	6
Sep 2011	7	5	3
Oct 2011	6	5	8
Nov 2011	6	10	6
Dec 2011	3	12	7
Total 2011	51	85	62
Jan 2012	3	3	5
Feb 2012	3	9	8
Mar 2012	5	5	3
Apr 2012	6	14	8
May 2012	2	7	5
Jun 2012	8	8	5
Jul 2012	11	7	4
Aug 2012	6	9	2
Sep 2012	3	2	1
Oct 2012	2	11	10
Nov 2012	4	4	5
Dec 2012	3	13	6
Total 2012	56	92	62
Jan 2013	6	10	1
Feb 2013	4	5	3
Mar 2013	4	6	3
Apr 2013	3	2	3
May 2013	1	9	5
Jun 2013	2	5	4
Jul 2013	8	2	2
Aug 2013	7	2	5
Sep 2013	4	4	1
Oct 2013	10	4	1
Nov 2013	4	8	5
Dec 2013	9	2	1
Total 2013	62	59	34
Jan 2014	10	4	1
Feb 2014	2	1	2
Mar 2014	6	3	4
Apr 2014	9	9	5
May 2014	9	6	2
Jun 2014	3	6	3
Jul 2014	10	7	8
Aug 2014	10	5	8
Sep 2014	9	6	18
Oct 2014	13	16	25
Nov 2014	9	9	17
Dec 2014	3	3	8
Total 2014	93	75	101
Jan 2015	13	9	8
Feb 2015	3	1	8
Mar 2015	6	3	8
Apr 2015	3	3	5
May 2015	3	4	5
Jun 2015	4	5	4
Jul 2015	4	7	10
Aug 2015	2	5	10
Sep 2015	19	4	6
Oct 2015	8	0	2
Nov 2015	3	6	6
Dec 2015	6	4	6
Total 2015	74	51	78
Jan 2016	6	3	4
Feb 2016	5	3	6
Mar 2016	5	4	10
Apr 2016	5	6	7
May 2016	13	3	7
Jun 2016	10	3	9
Jul 2016	5	6	8
Aug 2016	2	6	8
Sep 2016	10	3	3
Oct 2016	12	13	5
Nov 2016	2	17	0
Dec 2016	8	2	3
Total 2016	83	69	70
Jan 2017	1	7	5
Feb 2017	1	3	7
Mar 2017	1	7	6
Apr 2017	1	4	2
May 2017	2	2	0
Jun 2017	2	11	6
Jul 2017	1	4	2
Aug 2017	0	1	2
Sep 2017	0	6	6
Oct 2017	1	10	7
Nov 2017	0	12	3
Dec 2017	0	4	4
Total 2017	10	71	50
Jan 2018	4	9	7
Feb 2018	4	10	13
Mar 2018	1	12	7
Apr 2018	0	138	9
May 2018	0	82	3
Jun 2018	1	36	15
Jul 2018	1	22	4
Aug 2018	0	10	1
Sep 2018	0	9	6
Oct 2018	0	11	19
Nov 2018	0	16	6
Dec 2018	0	15	8
Total 2018	11	370	98
Jan 2019	2	11	4
Feb 2019	0	4	4
Mar 2019	0	4	8
Apr 2019	0	5	12
May 2019	1	9	9
Jun 2019	0	9	11
Jul 2019	0	8	8
Aug 2019	3	97	9
Sep 2019	0	87	8
Oct 2019	1	114	12
Nov 2019	0	19	5
Dec 2019	2	8	12
Total 2019	9	375	102
Jan 2020	2	20	12
Feb 2020	2	11	9
Mar 2020	0	7	13
Apr 2020	1	8	5
May 2020	5	5	5
Jun 2020	1	4	3
Jul 2020	3	1	6
Aug 2020	1	18	10
Sep 2020	2	21	5
Oct 2020	1	21	4
Nov 2020	2	4	3
Dec 2020	4	8	4
Total 2020	24	128	79
Jan 2021	0	1	0
Feb 2021	1	7	7
Mar 2021	1	9	12
Total 2021	2	17	19
Total	1108	2754	1586