Cutting Edge: Bacterial DNA and LPS Act in Synergy in Inducing Nitric Oxide Production in RAW 264.7 Macrophages

Jian Jun Gao; Eleanor G. Zuvanich; Qiao Xue; David L. Horn; Richard Silverstein; David C. Morrison

Article Information

vol. 163 no. 8 4095-4099

PubMed

10510342

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Received June 29, 1999
Accepted August 16, 1999
Published online October 15, 1999.

Author Information

Jian Jun Gao^*,
Eleanor G. Zuvanich^*,
Qiao Xue^*,
David L. Horn^‡,
Richard Silverstein^† and
David C. Morrison²,^*

Departments of
^*Microbiology, Molecular Genetics, and Immunology and
^†Biochemistry, University of Kansas Medical Center, Kansas City, KS 66160;
^‡U.S. Human Health Division, Merck & Company Inc., West Point, PA 19044;
^§Department of Basic Medical Sciences, University of Missouri, Kansas City, MO 64108; and
^¶Saint Luke’s Hospital of Kansas City, Kansas City, MO 64111

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	Abstract	Full	Pdf
Sep 2000	0	4	2
Oct 2000	2	25	16
Nov 2000	6	24	12
Dec 2000	5	20	16
Total 2000	13	73	46
Jan 2001	2	21	14
Feb 2001	1	14	95
Mar 2001	1	24	13
Apr 2001	8	13	17
May 2001	2	15	11
Jun 2001	5	13	16
Jul 2001	3	23	21
Aug 2001	0	20	17
Sep 2001	0	13	19
Oct 2001	1	16	16
Nov 2001	3	25	16
Dec 2001	2	26	18
Total 2001	28	223	273
Jan 2002	0	8	10
Feb 2002	0	13	14
Mar 2002	1	8	9
Apr 2002	1	14	9
May 2002	2	12	10
Jun 2002	1	7	10
Jul 2002	2	5	5
Aug 2002	3	13	12
Sep 2002	0	4	4
Oct 2002	0	8	14
Nov 2002	1	7	13
Dec 2002	1	11	10
Total 2002	12	110	120
Jan 2003	2	10	11
Feb 2003	0	9	15
Mar 2003	1	13	15
Apr 2003	0	9	5
May 2003	4	22	17
Jun 2003	2	4	8
Jul 2003	4	18	20
Aug 2003	7	15	7
Sep 2003	9	7	2
Oct 2003	7	16	12
Nov 2003	13	23	9
Dec 2003	9	27	10
Total 2003	58	173	131
Jan 2004	7	22	15
Feb 2004	4	13	7
Mar 2004	8	43	14
Apr 2004	10	23	11
May 2004	10	26	16
Jun 2004	8	23	14
Jul 2004	5	20	6
Aug 2004	10	21	13
Sep 2004	12	35	4
Oct 2004	9	35	14
Nov 2004	9	33	6
Dec 2004	8	35	6
Total 2004	100	329	126
Jan 2005	10	22	4
Feb 2005	7	21	11
Mar 2005	8	42	11
Apr 2005	12	22	12
May 2005	1	17	3
Jun 2005	4	14	6
Jul 2005	2	11	4
Aug 2005	5	17	7
Sep 2005	3	16	19
Oct 2005	4	17	4
Nov 2005	4	24	9
Dec 2005	2	14	8
Total 2005	62	237	98
Jan 2006	2	13	8
Feb 2006	5	13	6
Mar 2006	6	24	5
Apr 2006	6	25	9
May 2006	3	10	9
Jun 2006	3	9	5
Jul 2006	8	13	5
Aug 2006	3	13	7
Sep 2006	6	10	3
Oct 2006	5	24	10
Nov 2006	5	16	7
Dec 2006	4	23	12
Total 2006	56	193	86
Jan 2007	10	17	12
Feb 2007	4	15	6
Mar 2007	6	25	9
Apr 2007	7	18	10
May 2007	6	6	13
Jun 2007	5	7	3
Jul 2007	4	8	6
Aug 2007	5	8	6
Sep 2007	3	7	5
Oct 2007	3	24	16
Nov 2007	4	17	14
Dec 2007	8	12	11
Total 2007	65	164	111
Jan 2008	1	6	8
Feb 2008	4	2	10
Mar 2008	7	8	5
Apr 2008	8	10	11
May 2008	3	8	7
Jun 2008	19	18	18
Jul 2008	11	12	3
Aug 2008	5	10	11
Sep 2008	8	4	9
Oct 2008	3	0	8
Nov 2008	4	4	6
Dec 2008	4	7	8
Total 2008	77	89	104
Jan 2009	6	15	12
Feb 2009	7	6	7
Mar 2009	6	5	10
Apr 2009	8	7	11
May 2009	4	5	4
Jun 2009	1	6	12
Jul 2009	5	4	8
Aug 2009	4	0	4
Sep 2009	5	3	7
Oct 2009	1	6	8
Nov 2009	5	5	9
Dec 2009	3	4	6
Total 2009	55	66	98
Jan 2010	3	3	2
Feb 2010	5	2	8
Mar 2010	12	14	15
Apr 2010	6	8	11
May 2010	9	6	9
Jun 2010	6	10	12
Jul 2010	2	10	13
Aug 2010	4	8	5
Sep 2010	1	12	16
Oct 2010	5	10	11
Nov 2010	17	15	18
Dec 2010	9	5	8
Total 2010	79	103	128
Jan 2011	8	9	6
Feb 2011	10	6	7
Mar 2011	14	11	14
Apr 2011	7	6	20
May 2011	2	3	9
Jun 2011	13	11	14
Jul 2011	6	9	14
Aug 2011	16	6	13
Sep 2011	15	3	16
Oct 2011	18	5	10
Nov 2011	13	18	12
Dec 2011	14	8	8
Total 2011	136	95	143
Jan 2012	12	6	7
Feb 2012	14	4	14
Mar 2012	13	4	14
Apr 2012	10	1	16
May 2012	5	5	19
Jun 2012	18	4	11
Jul 2012	18	9	10
Aug 2012	9	8	10
Sep 2012	12	6	5
Oct 2012	7	6	3
Nov 2012	3	9	5
Dec 2012	9	5	6
Total 2012	130	67	120
Jan 2013	14	13	4
Feb 2013	7	28	6
Mar 2013	22	10	20
Apr 2013	10	3	9
May 2013	16	6	6
Jun 2013	7	3	8
Jul 2013	6	3	2
Aug 2013	10	3	5
Sep 2013	9	3	2
Oct 2013	13	6	7
Nov 2013	18	4	3
Dec 2013	9	1	6
Total 2013	141	83	78
Jan 2014	7	5	3
Feb 2014	9	3	9
Mar 2014	14	4	6
Apr 2014	6	5	6
May 2014	12	2	7
Jun 2014	10	4	4
Jul 2014	9	4	7
Aug 2014	8	5	4
Sep 2014	11	2	2
Oct 2014	5	3	5
Nov 2014	4	3	13
Dec 2014	5	3	5
Total 2014	100	43	71
Jan 2015	13	9	11
Feb 2015	5	5	8
Mar 2015	12	1	8
Apr 2015	41	3	12
May 2015	12	9	14
Jun 2015	8	3	7
Jul 2015	7	4	7
Aug 2015	4	4	8
Sep 2015	27	14	13
Oct 2015	6	1	6
Nov 2015	8	6	5
Dec 2015	3	5	7
Total 2015	146	64	106
Jan 2016	7	0	9
Feb 2016	4	1	7
Mar 2016	2	5	9
Apr 2016	5	6	5
May 2016	2	9	5
Jun 2016	4	9	15
Jul 2016	4	5	8
Aug 2016	2	13	3
Sep 2016	5	3	6
Oct 2016	10	9	1
Nov 2016	2	13	0
Dec 2016	5	9	2
Total 2016	52	82	70
Jan 2017	0	27	6
Feb 2017	2	34	9
Mar 2017	5	42	7
Apr 2017	5	34	4
May 2017	6	29	5
Jun 2017	7	8	3
Jul 2017	3	4	1
Aug 2017	1	5	3
Sep 2017	1	4	1
Oct 2017	3	9	3
Nov 2017	1	8	2
Dec 2017	5	8	7
Total 2017	39	212	51
Jan 2018	4	6	3
Feb 2018	3	20	7
Mar 2018	4	9	5
Apr 2018	4	56	4
May 2018	2	9	7
Jun 2018	5	4	16
Jul 2018	2	7	22
Aug 2018	2	6	18
Sep 2018	0	5	32
Oct 2018	0	19	30
Nov 2018	1	3	24
Dec 2018	0	3	14
Total 2018	27	147	182
Jan 2019	2	5	10
Feb 2019	2	6	7
Mar 2019	3	5	15
Apr 2019	1	4	19
May 2019	9	3	15
Jun 2019	6	4	8
Jul 2019	0	10	10
Aug 2019	2	7	40
Sep 2019	1	14	14
Oct 2019	2	31	9
Nov 2019	3	11	4
Dec 2019	2	9	5
Total 2019	33	109	156
Jan 2020	1	14	12
Feb 2020	1	4	8
Mar 2020	2	12	17
Apr 2020	1	9	5
May 2020	2	4	4
Jun 2020	1	2	3
Jul 2020	2	7	9
Aug 2020	4	7	13
Sep 2020	7	8	5
Oct 2020	3	16	6
Nov 2020	3	6	4
Dec 2020	2	6	3
Total 2020	29	95	89
Jan 2021	3	2	3
Feb 2021	2	4	5
Total 2021	5	6	8
Total	1443	2763	2395