Persistent T Cell Anergy in Human Type 1 Diabetes

H.-Michael Dosch; Roy K. Cheung; Wolfram Karges; Massimo Pietropaolo; Dorothy J. Becker

Article Information

vol. 163 no. 12 6933-6940

PubMed

10586096

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Received July 27, 1999
Accepted October 7, 1999
Published online December 15, 1999.

Author Information

H.-Michael Dosch²,^*,
Roy K. Cheung^*,
Wolfram Karges³,^*,
Massimo Pietropaolo^† and
Dorothy J. Becker^†

^*Departments of Pediatrics and Immunology, University of Toronto, The Hospital For Sick Children, Research Institute, Toronto, Ontario, Canada; and
^†Department of Pediatrics, University of Pittsburgh, Children’s Hospital, Pittsburgh, PA 15213

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Article usage

Article usage: October 2000 to January 2021

	Abstract	Full	Pdf
Oct 2000	3	18	8
Nov 2000	4	9	9
Dec 2000	3	28	20
Total 2000	10	55	37
Jan 2001	3	19	16
Feb 2001	1	12	9
Mar 2001	4	27	16
Apr 2001	3	14	9
May 2001	3	8	14
Jun 2001	3	12	19
Jul 2001	0	8	3
Aug 2001	1	20	11
Sep 2001	1	6	7
Oct 2001	2	19	15
Nov 2001	1	12	8
Dec 2001	2	8	5
Total 2001	24	165	132
Jan 2002	3	13	10
Feb 2002	0	10	9
Mar 2002	3	14	23
Apr 2002	4	12	12
May 2002	3	11	12
Jun 2002	1	8	8
Jul 2002	3	13	12
Aug 2002	4	12	9
Sep 2002	1	11	4
Oct 2002	1	15	14
Nov 2002	2	7	7
Dec 2002	2	8	4
Total 2002	27	134	124
Jan 2003	1	8	5
Feb 2003	1	11	10
Mar 2003	3	8	12
Apr 2003	0	20	19
May 2003	1	8	11
Jun 2003	2	10	9
Jul 2003	2	8	0
Aug 2003	8	12	0
Sep 2003	9	22	6
Oct 2003	10	9	5
Nov 2003	14	30	11
Dec 2003	9	17	1
Total 2003	60	163	89
Jan 2004	15	26	5
Feb 2004	5	17	6
Mar 2004	7	31	19
Apr 2004	7	17	4
May 2004	10	21	9
Jun 2004	9	16	17
Jul 2004	18	38	8
Aug 2004	13	20	6
Sep 2004	8	13	5
Oct 2004	7	34	14
Nov 2004	10	34	8
Dec 2004	12	22	8
Total 2004	121	289	109
Jan 2005	7	14	3
Feb 2005	12	26	11
Mar 2005	12	35	15
Apr 2005	3	15	12
May 2005	2	13	9
Jun 2005	2	13	3
Jul 2005	1	9	4
Aug 2005	3	24	4
Sep 2005	7	18	8
Oct 2005	7	27	12
Nov 2005	7	15	4
Dec 2005	4	13	5
Total 2005	67	222	90
Jan 2006	2	17	7
Feb 2006	6	10	4
Mar 2006	2	15	4
Apr 2006	2	10	6
May 2006	2	8	2
Jun 2006	3	8	4
Jul 2006	3	7	4
Aug 2006	3	8	6
Sep 2006	4	10	0
Oct 2006	5	18	11
Nov 2006	4	25	4
Dec 2006	44	44	15
Total 2006	80	180	67
Jan 2007	15	19	8
Feb 2007	3	6	4
Mar 2007	7	15	3
Apr 2007	6	15	8
May 2007	4	13	5
Jun 2007	4	15	7
Jul 2007	12	13	6
Aug 2007	2	6	4
Sep 2007	10	11	6
Oct 2007	5	14	10
Nov 2007	5	4	2
Dec 2007	1	6	4
Total 2007	74	137	67
Jan 2008	7	4	5
Feb 2008	2	11	5
Mar 2008	9	12	5
Apr 2008	7	10	7
May 2008	10	10	6
Jun 2008	9	15	5
Jul 2008	2	6	5
Aug 2008	10	5	4
Sep 2008	7	9	9
Oct 2008	4	12	9
Nov 2008	5	13	7
Dec 2008	8	9	5
Total 2008	80	116	72
Jan 2009	5	5	4
Feb 2009	4	6	1
Mar 2009	3	11	4
Apr 2009	8	8	1
May 2009	20	20	12
Jun 2009	3	4	5
Jul 2009	2	5	4
Aug 2009	3	8	3
Sep 2009	1	7	8
Oct 2009	3	5	5
Nov 2009	5	10	8
Dec 2009	3	9	6
Total 2009	60	98	61
Jan 2010	5	4	4
Feb 2010	10	5	6
Mar 2010	4	3	5
Apr 2010	7	5	8
May 2010	3	7	2
Jun 2010	4	9	3
Jul 2010	5	7	5
Aug 2010	5	2	6
Sep 2010	3	6	6
Oct 2010	4	10	2
Nov 2010	3	9	13
Dec 2010	2	3	5
Total 2010	55	70	65
Jan 2011	2	5	4
Feb 2011	2	10	11
Mar 2011	1	0	7
Apr 2011	7	5	3
May 2011	2	4	8
Jun 2011	5	2	3
Jul 2011	3	7	5
Aug 2011	6	0	8
Sep 2011	8	4	3
Oct 2011	2	3	3
Nov 2011	12	3	10
Dec 2011	3	6	2
Total 2011	53	49	67
Jan 2012	11	6	10
Feb 2012	5	5	8
Mar 2012	10	3	1
Apr 2012	6	6	5
May 2012	4	11	10
Jun 2012	15	14	2
Jul 2012	3	6	5
Aug 2012	7	4	2
Sep 2012	7	10	2
Oct 2012	6	7	6
Nov 2012	9	5	3
Dec 2012	11	8	7
Total 2012	94	85	61
Jan 2013	7	6	2
Feb 2013	13	13	2
Mar 2013	4	14	1
Apr 2013	3	4	0
May 2013	3	5	5
Jun 2013	4	5	7
Jul 2013	2	4	5
Aug 2013	1	1	2
Sep 2013	1	6	3
Oct 2013	4	2	2
Nov 2013	4	2	2
Dec 2013	1	0	1
Total 2013	47	62	32
Jan 2014	3	1	2
Feb 2014	3	2	2
Mar 2014	8	2	1
Apr 2014	3	2	4
May 2014	0	2	1
Jun 2014	2	3	1
Jul 2014	4	12	4
Aug 2014	1	2	10
Sep 2014	4	2	8
Oct 2014	2	5	12
Nov 2014	2	4	5
Dec 2014	2	2	7
Total 2014	34	39	57
Jan 2015	5	4	2
Feb 2015	3	3	6
Mar 2015	8	1	4
Apr 2015	3	1	2
May 2015	0	1	2
Jun 2015	4	3	2
Jul 2015	0	3	2
Aug 2015	1	4	4
Sep 2015	35	4	7
Oct 2015	24	3	1
Nov 2015	2	7	4
Dec 2015	3	24	4
Total 2015	88	58	40
Jan 2016	1	2	2
Feb 2016	4	2	3
Mar 2016	1	1	7
Apr 2016	6	4	7
May 2016	11	9	4
Jun 2016	2	5	7
Jul 2016	4	0	9
Aug 2016	1	3	1
Sep 2016	1	6	6
Oct 2016	0	3	3
Nov 2016	2	0	3
Dec 2016	2	2	1
Total 2016	35	37	53
Jan 2017	2	5	5
Feb 2017	0	7	4
Mar 2017	2	6	5
Apr 2017	0	7	3
May 2017	1	3	1
Jun 2017	0	3	4
Jul 2017	0	9	10
Aug 2017	2	0	0
Sep 2017	4	5	1
Oct 2017	0	8	0
Nov 2017	0	4	2
Dec 2017	0	3	3
Total 2017	11	60	38
Jan 2018	1	5	0
Feb 2018	0	5	4
Mar 2018	0	9	1
Apr 2018	1	2	1
May 2018	0	7	0
Jun 2018	0	8	2
Jul 2018	0	6	5
Aug 2018	0	6	1
Sep 2018	0	11	6
Oct 2018	1	14	4
Nov 2018	0	20	2
Dec 2018	0	7	3
Total 2018	3	100	29
Jan 2019	0	8	2
Feb 2019	1	9	5
Mar 2019	0	8	3
Apr 2019	1	2	1
May 2019	0	9	5
Jun 2019	1	5	1
Jul 2019	0	5	0
Aug 2019	5	267	7
Sep 2019	2	81	4
Oct 2019	3	73	7
Nov 2019	0	9	2
Dec 2019	1	9	4
Total 2019	14	485	41
Jan 2020	9	13	8
Feb 2020	1	4	1
Mar 2020	0	6	0
Apr 2020	0	6	0
May 2020	1	1	2
Jun 2020	1	1	0
Jul 2020	1	1	2
Aug 2020	0	8	1
Sep 2020	1	6	1
Oct 2020	1	20	1
Nov 2020	1	6	4
Dec 2020	6	6	5
Total 2020	22	78	25
Jan 2021	0	4	4
Total 2021	0	4	4
Total	1059	2686	1360