Increased Vaccine-Specific T Cell Frequency After Peptide-Based Vaccination Correlates with Increased Susceptibility to In Vitro Stimulation But Does Not Lead to Tumor Regression

Kang-Hun Lee; Ena Wang; Mai-Britt Nielsen; John Wunderlich; Steven Migueles; Mark Connors; Seth M. Steinberg; Steven A. Rosenberg; Francesco M. Marincola

Article Information

vol. 163 no. 11 6292-6300

PubMed

10570323

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Received July 16, 1999
Accepted September 14, 1999
Published online December 1, 1999.

Author Information

Kang-Hun Lee^*,
Ena Wang^†,
Mai-Britt Nielsen^†,
John Wunderlich^†,
Steven Migueles^§,
Mark Connors^§,
Seth M. Steinberg^‡,
Steven A. Rosenberg^† and
Francesco M. Marincola¹,^*,^†

^*Department of Transfusion Medicine, Clinical Center,
^†Surgery Branch, National Cancer Institute,
^‡Biostatistics and Data Management Section, National Cancer Institute, and
^§Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

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	Abstract	Full	Pdf
Sep 2000	3	4	7
Oct 2000	8	42	26
Nov 2000	4	22	25
Dec 2000	0	19	12
Total 2000	15	87	70
Jan 2001	3	33	25
Feb 2001	0	27	16
Mar 2001	3	20	19
Apr 2001	3	20	26
May 2001	0	20	18
Jun 2001	1	18	16
Jul 2001	4	23	30
Aug 2001	1	28	28
Sep 2001	5	16	28
Oct 2001	1	18	16
Nov 2001	2	23	25
Dec 2001	1	15	14
Total 2001	24	261	261
Jan 2002	1	22	21
Feb 2002	0	15	14
Mar 2002	1	13	20
Apr 2002	3	12	17
May 2002	2	23	23
Jun 2002	3	11	16
Jul 2002	1	12	29
Aug 2002	4	23	19
Sep 2002	5	17	21
Oct 2002	5	16	20
Nov 2002	7	18	23
Dec 2002	1	13	8
Total 2002	33	195	231
Jan 2003	3	13	20
Feb 2003	2	12	15
Mar 2003	0	14	30
Apr 2003	3	13	8
May 2003	1	11	10
Jun 2003	0	19	25
Jul 2003	4	17	15
Aug 2003	7	17	10
Sep 2003	8	21	13
Oct 2003	9	15	16
Nov 2003	7	24	29
Dec 2003	5	18	19
Total 2003	49	194	210
Jan 2004	8	19	13
Feb 2004	5	20	17
Mar 2004	8	21	28
Apr 2004	16	20	13
May 2004	6	25	13
Jun 2004	6	15	7
Jul 2004	9	20	8
Aug 2004	10	18	7
Sep 2004	20	32	10
Oct 2004	14	26	14
Nov 2004	25	30	15
Dec 2004	13	32	13
Total 2004	140	278	158
Jan 2005	8	39	9
Feb 2005	9	45	20
Mar 2005	12	37	5
Apr 2005	5	15	2
May 2005	4	18	5
Jun 2005	4	36	17
Jul 2005	3	27	18
Aug 2005	7	25	10
Sep 2005	2	26	13
Oct 2005	3	28	12
Nov 2005	5	22	13
Dec 2005	7	18	10
Total 2005	69	336	134
Jan 2006	5	15	8
Feb 2006	3	22	5
Mar 2006	1	24	6
Apr 2006	13	22	8
May 2006	12	10	11
Jun 2006	16	16	7
Jul 2006	11	10	5
Aug 2006	4	9	4
Sep 2006	5	5	2
Oct 2006	10	15	6
Nov 2006	9	12	9
Dec 2006	7	13	7
Total 2006	96	173	78
Jan 2007	11	14	12
Feb 2007	3	5	1
Mar 2007	11	22	9
Apr 2007	10	17	7
May 2007	10	7	5
Jun 2007	5	16	4
Jul 2007	9	12	2
Aug 2007	7	8	3
Sep 2007	6	6	2
Oct 2007	5	11	6
Nov 2007	4	14	13
Dec 2007	5	1	4
Total 2007	86	133	68
Jan 2008	6	9	10
Feb 2008	5	10	3
Mar 2008	16	9	3
Apr 2008	7	13	12
May 2008	6	7	5
Jun 2008	13	9	8
Jul 2008	8	12	1
Aug 2008	14	9	4
Sep 2008	8	30	2
Oct 2008	10	5	6
Nov 2008	6	7	3
Dec 2008	5	6	8
Total 2008	104	126	65
Jan 2009	11	8	8
Feb 2009	7	4	5
Mar 2009	5	13	8
Apr 2009	5	4	5
May 2009	5	8	3
Jun 2009	8	9	7
Jul 2009	6	5	5
Aug 2009	5	4	9
Sep 2009	8	9	7
Oct 2009	8	5	5
Nov 2009	10	3	5
Dec 2009	4	3	6
Total 2009	82	75	73
Jan 2010	7	9	7
Feb 2010	7	5	2
Mar 2010	14	7	8
Apr 2010	8	8	3
May 2010	10	12	10
Jun 2010	4	3	14
Jul 2010	4	8	9
Aug 2010	4	6	7
Sep 2010	9	3	4
Oct 2010	4	3	5
Nov 2010	3	12	9
Dec 2010	9	5	6
Total 2010	83	81	84
Jan 2011	4	8	9
Feb 2011	7	8	12
Mar 2011	11	8	9
Apr 2011	10	5	6
May 2011	12	8	9
Jun 2011	10	8	8
Jul 2011	6	11	8
Aug 2011	9	4	7
Sep 2011	14	10	15
Oct 2011	15	7	10
Nov 2011	18	9	8
Dec 2011	3	13	6
Total 2011	119	99	107
Jan 2012	16	5	9
Feb 2012	16	13	5
Mar 2012	9	9	9
Apr 2012	11	8	16
May 2012	13	6	5
Jun 2012	7	10	8
Jul 2012	15	9	7
Aug 2012	7	5	5
Sep 2012	11	5	11
Oct 2012	7	7	4
Nov 2012	9	16	10
Dec 2012	17	11	8
Total 2012	138	104	97
Jan 2013	20	15	2
Feb 2013	15	4	5
Mar 2013	18	10	5
Apr 2013	17	3	3
May 2013	17	7	9
Jun 2013	11	6	7
Jul 2013	17	4	2
Aug 2013	2	1	0
Sep 2013	5	9	10
Oct 2013	16	6	6
Nov 2013	14	4	4
Dec 2013	10	6	3
Total 2013	162	75	56
Jan 2014	7	3	4
Feb 2014	7	1	2
Mar 2014	6	8	4
Apr 2014	19	7	7
May 2014	23	8	4
Jun 2014	8	2	2
Jul 2014	9	11	12
Aug 2014	6	6	4
Sep 2014	14	5	3
Oct 2014	10	8	8
Nov 2014	9	6	16
Dec 2014	11	2	6
Total 2014	129	67	72
Jan 2015	4	4	14
Feb 2015	11	5	14
Mar 2015	5	6	7
Apr 2015	4	4	2
May 2015	9	1	6
Jun 2015	6	13	7
Jul 2015	9	8	11
Aug 2015	1	4	4
Sep 2015	26	5	5
Oct 2015	22	4	4
Nov 2015	9	3	9
Dec 2015	4	0	1
Total 2015	110	57	84
Jan 2016	20	8	18
Feb 2016	7	4	15
Mar 2016	12	9	12
Apr 2016	10	9	10
May 2016	7	5	7
Jun 2016	16	1	5
Jul 2016	6	3	12
Aug 2016	9	6	5
Sep 2016	10	9	9
Oct 2016	6	6	6
Nov 2016	15	3	4
Dec 2016	4	3	7
Total 2016	122	66	110
Jan 2017	12	10	8
Feb 2017	3	3	5
Mar 2017	2	9	4
Apr 2017	5	6	4
May 2017	1	4	6
Jun 2017	4	10	9
Jul 2017	9	8	6
Aug 2017	4	1	2
Sep 2017	7	11	10
Oct 2017	3	31	7
Nov 2017	6	7	4
Dec 2017	5	15	5
Total 2017	61	115	70
Jan 2018	1	8	3
Feb 2018	4	5	6
Mar 2018	5	10	9
Apr 2018	0	8	3
May 2018	6	13	5
Jun 2018	2	35	10
Jul 2018	1	6	3
Aug 2018	4	10	5
Sep 2018	4	11	4
Oct 2018	7	27	6
Nov 2018	1	23	10
Dec 2018	0	11	4
Total 2018	35	167	68
Jan 2019	3	19	2
Feb 2019	6	8	5
Mar 2019	7	13	11
Apr 2019	7	12	5
May 2019	2	8	6
Jun 2019	0	2	3
Jul 2019	1	7	1
Aug 2019	5	242	6
Sep 2019	0	177	8
Oct 2019	9	227	5
Nov 2019	3	40	4
Dec 2019	4	20	12
Total 2019	47	775	68
Jan 2020	6	43	9
Feb 2020	3	9	4
Mar 2020	2	7	2
Apr 2020	3	10	3
May 2020	6	6	5
Jun 2020	1	7	2
Jul 2020	2	7	2
Aug 2020	0	10	0
Sep 2020	6	25	5
Oct 2020	2	20	2
Nov 2020	5	43	5
Dec 2020	5	13	9
Total 2020	41	200	48
Total	1745	3664	2212