Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

Jun Shimizu; Sayuri Yamazaki; Shimon Sakaguchi

Article Information

vol. 163 no. 10 5211-5218

PubMed

10553041

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Received April 26, 1999
Accepted August 25, 1999
Published online November 15, 1999.

Author Information

Jun Shimizu^*,
Sayuri Yamazaki^† and
Shimon Sakaguchi²,^*,^†

^*Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; and
^†Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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Article usage

Article usage: September 2000 to April 2022

	Abstract	Full	Pdf
Sep 2000	1	4	7
Oct 2000	2	19	21
Nov 2000	4	48	25
Dec 2000	3	28	26
Total 2000	10	99	79
Jan 2001	3	34	29
Feb 2001	0	45	52
Mar 2001	3	26	28
Apr 2001	0	37	41
May 2001	0	41	42
Jun 2001	6	46	57
Jul 2001	2	43	58
Aug 2001	5	43	44
Sep 2001	4	44	46
Oct 2001	4	66	73
Nov 2001	10	56	69
Dec 2001	3	30	27
Total 2001	40	511	566
Jan 2002	1	57	61
Feb 2002	8	54	65
Mar 2002	9	36	67
Apr 2002	5	58	44
May 2002	15	55	59
Jun 2002	0	42	59
Jul 2002	3	28	44
Aug 2002	1	44	55
Sep 2002	6	19	47
Oct 2002	3	48	71
Nov 2002	1	32	60
Dec 2002	4	29	61
Total 2002	56	502	693
Jan 2003	3	31	61
Feb 2003	8	41	57
Mar 2003	7	47	69
Apr 2003	4	53	62
May 2003	3	43	59
Jun 2003	1	41	34
Jul 2003	11	47	51
Aug 2003	10	35	42
Sep 2003	18	61	59
Oct 2003	22	55	83
Nov 2003	25	49	60
Dec 2003	13	54	72
Total 2003	125	557	709
Jan 2004	20	56	59
Feb 2004	15	73	76
Mar 2004	15	78	83
Apr 2004	12	85	74
May 2004	14	72	49
Jun 2004	19	60	70
Jul 2004	26	69	66
Aug 2004	24	74	73
Sep 2004	25	60	71
Oct 2004	29	92	90
Nov 2004	28	82	87
Dec 2004	38	88	77
Total 2004	265	889	875
Jan 2005	34	87	85
Feb 2005	26	94	72
Mar 2005	27	112	72
Apr 2005	21	74	68
May 2005	28	81	64
Jun 2005	15	63	74
Jul 2005	9	61	61
Aug 2005	22	85	63
Sep 2005	13	66	59
Oct 2005	34	96	88
Nov 2005	19	73	71
Dec 2005	34	63	54
Total 2005	282	955	831
Jan 2006	16	79	65
Feb 2006	28	63	55
Mar 2006	23	84	64
Apr 2006	41	82	60
May 2006	32	59	54
Jun 2006	21	44	36
Jul 2006	21	65	51
Aug 2006	15	51	44
Sep 2006	24	60	52
Oct 2006	23	78	52
Nov 2006	32	57	54
Dec 2006	21	37	38
Total 2006	297	759	625
Jan 2007	21	57	58
Feb 2007	19	25	33
Mar 2007	24	43	33
Apr 2007	13	66	53
May 2007	17	42	63
Jun 2007	25	47	37
Jul 2007	21	56	34
Aug 2007	27	40	41
Sep 2007	38	53	47
Oct 2007	22	60	39
Nov 2007	37	53	50
Dec 2007	17	51	37
Total 2007	281	593	525
Jan 2008	9	40	36
Feb 2008	16	42	31
Mar 2008	27	53	43
Apr 2008	22	48	51
May 2008	24	47	61
Jun 2008	22	45	30
Jul 2008	14	46	31
Aug 2008	18	38	30
Sep 2008	9	41	29
Oct 2008	15	56	49
Nov 2008	17	36	43
Dec 2008	13	40	46
Total 2008	206	532	480
Jan 2009	19	29	24
Feb 2009	23	34	34
Mar 2009	29	41	43
Apr 2009	27	37	47
May 2009	17	37	32
Jun 2009	17	33	30
Jul 2009	26	54	38
Aug 2009	25	38	25
Sep 2009	20	44	38
Oct 2009	15	41	34
Nov 2009	22	25	30
Dec 2009	21	30	30
Total 2009	261	443	405
Jan 2010	20	29	29
Feb 2010	27	41	41
Mar 2010	32	32	39
Apr 2010	29	46	29
May 2010	18	37	50
Jun 2010	16	40	26
Jul 2010	21	31	28
Aug 2010	22	19	28
Sep 2010	23	56	29
Oct 2010	27	44	35
Nov 2010	34	48	37
Dec 2010	18	30	17
Total 2010	287	453	388
Jan 2011	42	30	32
Feb 2011	13	24	17
Mar 2011	33	48	37
Apr 2011	27	26	27
May 2011	35	33	31
Jun 2011	14	19	35
Jul 2011	23	19	18
Aug 2011	22	27	23
Sep 2011	53	27	32
Oct 2011	64	50	35
Nov 2011	58	41	44
Dec 2011	67	26	19
Total 2011	451	370	350
Jan 2012	42	29	21
Feb 2012	57	53	30
Mar 2012	50	34	27
Apr 2012	48	46	36
May 2012	57	58	37
Jun 2012	36	27	25
Jul 2012	48	24	29
Aug 2012	45	24	22
Sep 2012	43	23	26
Oct 2012	61	54	50
Nov 2012	45	23	28
Dec 2012	46	27	23
Total 2012	578	422	354
Jan 2013	61	44	35
Feb 2013	57	28	21
Mar 2013	56	35	30
Apr 2013	45	42	30
May 2013	47	48	28
Jun 2013	38	24	18
Jul 2013	61	27	18
Aug 2013	45	20	20
Sep 2013	45	20	18
Oct 2013	41	25	21
Nov 2013	39	25	29
Dec 2013	41	23	18
Total 2013	576	361	286
Jan 2014	58	23	24
Feb 2014	38	20	19
Mar 2014	55	39	27
Apr 2014	65	40	24
May 2014	68	35	25
Jun 2014	68	22	24
Jul 2014	76	30	22
Aug 2014	44	34	19
Sep 2014	45	41	16
Oct 2014	47	27	17
Nov 2014	36	20	13
Dec 2014	30	24	21
Total 2014	630	355	251
Jan 2015	33	23	20
Feb 2015	50	31	23
Mar 2015	60	43	40
Apr 2015	32	34	21
May 2015	53	38	27
Jun 2015	39	29	22
Jul 2015	72	29	28
Aug 2015	43	20	18
Sep 2015	73	38	35
Oct 2015	99	59	37
Nov 2015	54	19	22
Dec 2015	70	28	25
Total 2015	678	391	318
Jan 2016	67	15	22
Feb 2016	54	29	17
Mar 2016	32	45	20
Apr 2016	34	34	25
May 2016	36	37	15
Jun 2016	59	37	24
Jul 2016	29	24	20
Aug 2016	23	24	19
Sep 2016	63	32	22
Oct 2016	63	35	12
Nov 2016	80	110	27
Dec 2016	32	78	15
Total 2016	572	500	238
Jan 2017	14	63	21
Feb 2017	7	75	26
Mar 2017	14	107	35
Apr 2017	16	55	29
May 2017	5	43	29
Jun 2017	9	30	19
Jul 2017	6	67	12
Aug 2017	11	35	12
Sep 2017	13	47	21
Oct 2017	9	39	28
Nov 2017	10	60	30
Dec 2017	20	60	27
Total 2017	134	681	289
Jan 2018	12	48	16
Feb 2018	10	56	21
Mar 2018	15	68	31
Apr 2018	37	64	33
May 2018	10	55	14
Jun 2018	9	55	15
Jul 2018	10	50	23
Aug 2018	11	69	24
Sep 2018	4	77	22
Oct 2018	12	59	23
Nov 2018	10	95	37
Dec 2018	9	43	21
Total 2018	149	739	280
Jan 2019	15	61	28
Feb 2019	7	57	26
Mar 2019	12	70	31
Apr 2019	12	51	32
May 2019	15	47	26
Jun 2019	8	38	18
Jul 2019	15	65	34
Aug 2019	5	511	18
Sep 2019	8	663	20
Oct 2019	8	1069	31
Nov 2019	18	315	26
Dec 2019	0	59	18
Total 2019	123	3006	308
Jan 2020	10	128	22
Feb 2020	6	192	11
Mar 2020	15	44	26
Apr 2020	12	42	25
May 2020	15	58	21
Jun 2020	13	46	17
Jul 2020	4	63	17
Aug 2020	6	95	12
Sep 2020	9	112	19
Oct 2020	6	122	24
Nov 2020	7	84	17
Dec 2020	11	98	26
Total 2020	114	1084	237
Jan 2021	13	62	18
Feb 2021	7	76	26
Mar 2021	11	86	23
Apr 2021	11	63	18
May 2021	5	104	26
Jun 2021	2	88	19
Jul 2021	6	64	22
Aug 2021	5	50	13
Sep 2021	7	110	18
Oct 2021	8	332	23
Nov 2021	17	65	34
Dec 2021	6	31	11
Total 2021	98	1131	251
Jan 2022	5	49	8
Feb 2022	4	26	16
Mar 2022	12	37	10
Apr 2022	11	44	23
Total 2022	32	156	57
Total	6245	15489	9395