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Peptide Position Sequence A11 Binding Capacity (nM IC50) CTL Responsea Peptide immunization PR8 (FLU) immunization No. positive/ no. tested LU30/106 cellsb No. positive/ no. tested LU30/106 cells Hemagglutinin 63 GIAPLQLGK 30 3/6 11.8 (2.4) 0/5 —c 149 VTAACSHAGK 121 3/6 11.8 (2.0) 0/5 — 243 RMNYYWTLLK 2.6 2/6 4.3 (1.5) 0/5 — 450 RTLDFHDSNVK 51 6/6 10.3 (1.8) 5/5 14.0 (2.2) 495 SVRNGTYDYPK 44 6/6 7.1 (2.3) 0/5 — Matrix 1 13 SIIPSGPLK 0.7 6/6 24.3 (2.0) 0/5 — 178 RMVLASTTAK 169 3/6 90.1 (1.3) 0/5 — 220 GTHPSSSAGLK 94 6/6 23.5 (1.3) 0/5 — Matrix 2 70 KSMREEYRK 75 3/6 12.9 (1.2) 0/5 — Nuclear protein 188 TMVMELVRMIK 193 6/6 18.9 (2.0) 0/5 — 342 RVLSFIKGTK 72 3/6 3.5 (1.6) 0/5 — a Peptide-pulsed .221 A11/Kb target cells.
b Geometric mean of positive cultures (×/÷ SD).
c Indicates no response detected.
