The Journal of Immunology: 161 (12)

December 15, 1998; Volume 161,Issue 12

EDITORIALS

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Clinical Immunology and The Journal of Immunology
Frank W. Fitch

J Immunol December 15, 1998, 161 (12)

CUTTING EDGE

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Cutting Edge: Virus-Activated CD8 T Cells and Lymphokine-Activated NK Cells Express the Mast Cell Function-Associated Antigen, An Inhibitory C-Type Lectin
Claudine Blaser, Martina Kaufmann and Hanspeter Pircher

J Immunol December 15, 1998, 161 (12) 6451-6454;
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Cutting Edge: Nuclear Factor of Activated T Cells and AP-1 Are Insufficient for IL-2 Promoter Activation: Requirement for CD28 Up-Regulation of RE/AP
Virginia Smith Shapiro, Marianne Newton Mollenauer and Arthur Weiss

J Immunol December 15, 1998, 161 (12) 6455-6458;
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Cutting Edge: TCR Signaling Induces Selective Exclusion of CD43 from the T Cell-Antigen-Presenting Cell Contact Site
Anne I. Sperling, John R. Sedy, N. Manjunath, Abraham Kupfer, Blair Ardman and Janis K. Burkhardt

J Immunol December 15, 1998, 161 (12) 6459-6462;
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Cutting Edge: Impaired Mast Cell Development and Innate Immunity in Mac-1 (CD11b/CD18, CR3)-Deficient Mice
Alexander R. Rosenkranz, Angela Coxon, Marcus Maurer, Michael F. Gurish, K. Frank Austen, Daniel S. Friend, Stephen J. Galli and Tanya N. Mayadas

J Immunol December 15, 1998, 161 (12) 6463-6467;

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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Increased Activity of Oleate-Dependent Type Phospholipase D During Actinomycin D-Induced Apoptosis in Jurkat T Cells
Takeshi Kasai, Kenji Ohguchi, Shigeru Nakashima, Yuzuru Ito, Takashi Naganawa, Naomi Kondo and Yoshinori Nozawa

J Immunol December 15, 1998, 161 (12) 6469-6474;
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MHC Class I Mosaic Mice Reveal Insights into Control of Ly49C Inhibitory Receptor Expression in NK Cells
Malena Andersson, Sofia Freland, Maria H. Johansson, Robert Wallin, Johan K. Sandberg, Benedict J. Chambers, Birger Christensson, Urban Lendahl, Suzanne Lemieux, Margarita Salcedo and Hans-Gustaf Ljunggren

J Immunol December 15, 1998, 161 (12) 6475-6479;
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IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells
Elena B. Samoilova, Jennifer L. Horton, Brendan Hilliard, Tzu-Shang T. Liu and Youhai Chen

J Immunol December 15, 1998, 161 (12) 6480-6486;
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Inside the Crawling T Cell: Leukocyte Function-Associated Antigen-1 Cross-Linking Is Associated with Microtubule-Directed Translocation of Protein Kinase C Isoenzymes β(I) and δ
Yuri Volkov, Aideen Long and Dermot Kelleher

J Immunol December 15, 1998, 161 (12) 6487-6495;
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CD27/CD70 Interaction Augments IgE Secretion by Promoting the Differentiation of Memory B Cells into Plasma Cells
Haruo Nagumo, Kazunaga Agematsu, Koji Shinozaki, Sho Hokibara, Susumu Ito, Masaya Takamoto, Toshio Nikaido, Kozo Yasui, Yoshio Uehara, Akihiro Yachie and Atsushi Komiyama

J Immunol December 15, 1998, 161 (12) 6496-6502;
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Stimulation of Stat5 by Granulocyte Colony-Stimulating Factor (G-CSF) Is Modulated by Two Distinct Cytoplasmic Regions of the G-CSF Receptor
Fan Dong, Xiuwen Liu, John P. de Koning, Ivo P. Touw, Lothar Henninghausen, Andrew Larner and Philip M. Grimley

J Immunol December 15, 1998, 161 (12) 6503-6509;
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Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses
Irene Gramaglia, Andrew D. Weinberg, Michael Lemon and Michael Croft

J Immunol December 15, 1998, 161 (12) 6510-6517;
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Epitope-Specific Antibody and Suppression of Autoantibody Responses Against a Hybrid Self Protein
Gerald L. Lohnas, Steven F. Roberts, Aprile Pilon and Alfonso Tramontano

J Immunol December 15, 1998, 161 (12) 6518-6525;
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Nitric Oxide Synthase Plays a Signaling Role in TCR-Triggered Apoptotic Death
Mark S. Williams, Soichi Noguchi, Pierre A. Henkart and Yoichi Osawa

J Immunol December 15, 1998, 161 (12) 6526-6531;
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Cytotoxic T Cell Responses to DNA Vaccination: Dependence on Antigen Presentation via Class II MHC
Holden T. Maecker, Dale T. Umetsu, Rosemarie H. DeKruyff and Shoshana Levy

J Immunol December 15, 1998, 161 (12) 6532-6536;
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Complement Opsonization Is Required for Presentation of Immune Complexes by Resting Peripheral Blood B Cells
Susan A. Boackle, Margaret A. Morris, V. Michael Holers and David R. Karp

J Immunol December 15, 1998, 161 (12) 6537-6543;
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Regulation of NK1.1 Expression During Lineage Commitment of Progenitor Thymocytes
James R. Carlyle and Juan Carlos Zúñiga-Pflücker

J Immunol December 15, 1998, 161 (12) 6544-6551;
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Importance of B7-1-Expressing Host Antigen-Presenting Cells for the Eradication of B7-2 Transfected P815 Tumor Cells
Ross N. La Motte, Arlene H. Sharpe, Jeffrey A. Bluestone and Margalit B. Mokyr

J Immunol December 15, 1998, 161 (12) 6552-6558;
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Coreceptor-Independent T Cell Activation in Mice Expressing MHC Class II Molecules Mutated in the CD4 Binding Domain
Elahe A. Mostaghel, Janice M. Riberdy, Douglas A. Steeber and Carolyn Doyle

J Immunol December 15, 1998, 161 (12) 6559-6566;
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The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs
Lars Rogge, Daniele D’Ambrosio, Mauro Biffi, Giuseppe Penna, Lisa J. Minetti, David H. Presky, Luciano Adorini and Francesco Sinigaglia

J Immunol December 15, 1998, 161 (12) 6567-6574;
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Antagonistic Roles for Phospholipase D Activities in B Cell Signaling: While the Antigen Receptors Transduce Mitogenic Signals Via a Novel Phospholipase D Activity, Phosphatidylcholine-Phospholipase D Mediates Antiproliferative Signals
Jonathan J. Gilbert, Trevor R. Pettitt, Sandra D. Seatter, Steven D. Reid, Michael J. O. Wakelam and Margaret M. Harnett

J Immunol December 15, 1998, 161 (12) 6575-6584;
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Induction or Protection from Experimental Autoimmune Encephalomyelitis Depends on the Cytokine Secretion Profile of TCR Peptide-Specific Regulatory CD4 T Cells
Vipin Kumar and Eli Sercarz

J Immunol December 15, 1998, 161 (12) 6585-6591;
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The Development of Autoimmune Inflammatory Arthropathy in Mice Transgenic for the Human T Cell Leukemia Virus Type-1 env-pX Region Is Not Dependent on H-2 Haplotypes and Modified by the Expression Levels of Fas Antigen
Yoichiro Iwakura, Keiko Itagaki, Chiho Ishitsuka, Yoshiki Yamasaki, Akio Matsuzawa, Shin Yonehara, Shigeru Karasawa, Susumu Ueda and Shinobu Saijo

J Immunol December 15, 1998, 161 (12) 6592-6598;
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Differential Effects of Peptide Diversity and Stromal Cell Type in Positive and Negative Selection in the Thymus
Graham Anderson, Katharine M. Partington and Eric J. Jenkinson

J Immunol December 15, 1998, 161 (12) 6599-6603;
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Loss of Original Antigenic Specificity in T Cell Hybridomas Transduced with a Chimeric Receptor Containing Single-Chain Fv of an Anti-Collagen Antibody and FcεRI-Signaling γ Subunit
Alexander E. Annenkov, Sasha P. Moyes, Zelig Eshhar, Rizgar A. Mageed and Yuti Chernajovsky

J Immunol December 15, 1998, 161 (12) 6604-6613;
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Differential Effects of CD28 Engagement and IL-12 on T Cell Activation by Altered Peptide Ligands
Linna Ding and Ethan M. Shevach

J Immunol December 15, 1998, 161 (12) 6614-6621;
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T Cell Proliferation-Augmenting Activities of the Gene 3 Protein Derived from a Phage Library Clone with CD80-Binding Activity
Takahiro Fukumoto, Naohiko Torigoe, Yuji Ito, Yasuhiro Kajiwara and Kazuhisa Sugimura

J Immunol December 15, 1998, 161 (12) 6622-6628;
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Selection and Function of CD4⁺ T Lymphocytes in Transgenic Mice Expressing Mutant MHC Class II Molecules Deficient in Their Interaction with CD4
Susan Gilfillan, Xiaoli Shen and Rolf König3

J Immunol December 15, 1998, 161 (12) 6629-6637;
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Efficient Lymphocyte Migration Across High Endothelial Venules of Mouse Peyer’s Patches Requires Overlapping Expression of L-Selectin and β₇ Integrin
Douglas A. Steeber, Mimi L. K. Tang, Xiu-Qin Zhang, Werner Müller, Norbert Wagner and Thomas F. Tedder

J Immunol December 15, 1998, 161 (12) 6638-6647;

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Dependence of Both Spontaneous and Antibody-Dependent, Granule Exocytosis-Mediated NK Cell Cytotoxicity on Extracellular Signal-Regulated Kinases
Rossana Trotta, Kristin A. Puorro, Marino Paroli, Livio Azzoni, Bekele Abebe, Laurence C. Eisenlohr and Bice Perussia

J Immunol December 15, 1998, 161 (12) 6648-6656;

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Terminal Deoxynucleotidyl Transferase Expression During Neonatal Life Alters D_H Reading Frame Usage and Ig-Receptor-Dependent Selection of V Regions
Aaron J. Marshall, Noelle Doyen, Laurent A. Bentolila, Christopher J. Paige and Gillian E. Wu

J Immunol December 15, 1998, 161 (12) 6657-6663;
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Transcriptional Suppression of Matrix Metalloproteinase-2 Gene Expression in Human Astroglioma Cells by TNF-α and IFN-γ
Hongwei Qin, Jason D. Moellinger, Alan Wells, L. Jack Windsor, Yi Sun and Etty N. Benveniste

J Immunol December 15, 1998, 161 (12) 6664-6673;
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Clonal Expansion Within CD4⁺ and CD8⁺ T Cell Subsets in Human T Lymphotropic Virus Type I-Infected Individuals
Nobutaka Eiraku, Ravi Hingorani, Shinji Ijichi, Koichi Machigashira, Peter K. Gregersen, Joanita Monteiro, Koichiro Usuku, Shinji Yashiki, Shunro Sonoda, Mitsuhiro Osame and William W. Hall

J Immunol December 15, 1998, 161 (12) 6674-6680;
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Structural Basis of the gp120 Superantigen-Binding Site on Human Immunoglobulins
Saoussen Karray, Laure Juompan, Rachid C. Maroun, David Isenberg, Gregg J. Silverman and Moncef Zouali

J Immunol December 15, 1998, 161 (12) 6681-6688;
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Redox Regulation of Caspase-3(-like) Protease Activity: Regulatory Roles of Thioredoxin and Cytochrome c
Shugo Ueda, Hajime Nakamura, Hiroshi Masutani, Tetsuro Sasada, Shin Yonehara, Arimichi Takabayashi, Yoshio Yamaoka and Junji Yodoi

J Immunol December 15, 1998, 161 (12) 6689-6695;
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Production of a Chimeric Form of CD23 That Is Oligomeric and Blocks IgE Binding to the FcεRI
Ann E. Kelly, Bing-Hung Chen, Elaine C. Woodward and Daniel H. Conrad

J Immunol December 15, 1998, 161 (12) 6696-6704;
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HLA (A*0201) Mimicry by Anti-Idiotypic Monoclonal Antibodies
William J. Burlingham, Ewa Jankowska-Gan, Lynn DeVito-Haynes, John H. Fechner Jr., Kevin T. Hogan, Frans H. J. Claas, Arend Mulder, Xinhui Wang and Soldano Ferrone

J Immunol December 15, 1998, 161 (12) 6705-6714;
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Two Families of GTPases Dominate the Complex Cellular Response to IFN-γ
Ulrich Boehm, Lisbeth Guethlein, Thorsten Klamp, Kural Ozbek, Annette Schaub, Agnes Fütterer, Klaus Pfeffer and Jonathan C. Howard

J Immunol December 15, 1998, 161 (12) 6715-6723;
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Marsupial Light Chains: Complexity and Conservation of λ in the Opossum Monodelphis domestica
Julie E. Lucero, George H. Rosenberg and Robert D. Miller

J Immunol December 15, 1998, 161 (12) 6724-6732;
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MEK and ERK Activation in Ras-Disabled RBL-2H3 Mast Cells and Novel Roles for Geranylgeranylated and Farnesylated Proteins in FcεRI-Mediated Signaling
Timothy E. Graham, Janet R. Pfeiffer, Rebecca J. Lee, Donna F. Kusewitt, A. Marina Martinez, Terry Foutz, Bridget S. Wilson and Janet M. Oliver

J Immunol December 15, 1998, 161 (12) 6733-6744;
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A Region of Conformational Variability Outside the Peptide-Binding Site of a Class I MHC Molecule
Scott T. Kuhns and Larry R. Pease

J Immunol December 15, 1998, 161 (12) 6745-6750;
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CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter
Meng-Jiao Shi and Janet Stavnezer

J Immunol December 15, 1998, 161 (12) 6751-6760;

HOST DEFENSE

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Antitumor Response Elicited by a Superantigen- Transmembrane Sequence Fusion Protein Anchored onto Tumor Cells
Jennifer L. Wahlsten, Charles D. Mills and S. Ramakrishnan

J Immunol December 15, 1998, 161 (12) 6761-6767;
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Analysis of Signal Transduction Pathways Regulating Cytokine-Mediated Fc Receptor Activation on Human Eosinophils
Madelon Bracke, Paul J. Coffer, Jan-Willem J. Lammers and Leo Koenderman

J Immunol December 15, 1998, 161 (12) 6768-6774;
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Resistance to the African Trypanosomes Is IFN-γ Dependent
Cheryl J. Hertz, Hanna Filutowicz and John M. Mansfield

J Immunol December 15, 1998, 161 (12) 6775-6783;
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Coelomocytes Express SpBf, a Homologue of Factor B, the Second Component in the Sea Urchin Complement System
L. Courtney Smith, Chi-Schin Shih and Sebastian G. Dachenhausen

J Immunol December 15, 1998, 161 (12) 6784-6793;
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Leishmania mexicana Cysteine Proteinase-Deficient Mutants Have Attenuated Virulence for Mice and Potentiate a Th1 Response
James Alexander, Graham H. Coombs and Jeremy C. Mottram

J Immunol December 15, 1998, 161 (12) 6794-6801;
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MRL/lpr and MRL^+/+ Macrophage DNA Synthesis in the Absence and the Presence of Colony-Stimulating Factor-1 and Granulocyte-Macrophage Colony-Stimulating Factor
John A. Hamilton, James Chan, Robert J. Byrne, Robert J. Bischof, Anthony Jaworowski and Varuni Kanagasundaram

J Immunol December 15, 1998, 161 (12) 6802-6811;
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Alteration of Intracellular Calcium Flux and Impairment of Nuclear Factor-AT Translocation in T Cells During Acute Toxoplasma gondii Infection in Mice
Sakhina Haque, Henri Dumon, Azizul Haque and Lloyd H. Kasper

J Immunol December 15, 1998, 161 (12) 6812-6818;
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Expression of the Third Component of Complement, C3, in Regenerating Limb Blastema Cells of Urodeles
Katia Del Rio-Tsonis, Panagiotis A. Tsonis, Ioannis K. Zarkadis, Andreas G. Tsagas and John D. Lambris

J Immunol December 15, 1998, 161 (12) 6819-6824;

INFLAMMATION

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Interaction of Very Late Antigen-4 with VCAM-1 Supports Transendothelial Chemotaxis of Monocytes by Facilitating Lateral Migration
Christian Weber and Timothy A. Springer

J Immunol December 15, 1998, 161 (12) 6825-6834;
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Contribution of Dermal Macrophage Trafficking in the Sensitization Phase of Contact Hypersensitivity
Kayoko Sato, Yasuyuki Imai and Tatsuro Irimura

J Immunol December 15, 1998, 161 (12) 6835-6844;
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Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization
Lynn A. Cornelius, Leslie C. Nehring, Elizabeth Harding, Mark Bolanowski, Howard G. Welgus, Dale K. Kobayashi, Richard A. Pierce and Steven D. Shapiro

J Immunol December 15, 1998, 161 (12) 6845-6852;
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Lymphotoxin α3 Induces Chemokines and Adhesion Molecules: Insight into the Role of LTα in Inflammation and Lymphoid Organ Development
Carolyn A. Cuff, Jessica Schwartz, Cheryl M. Bergman, Kerry S. Russell, Jeffrey R. Bender and Nancy H. Ruddle

J Immunol December 15, 1998, 161 (12) 6853-6860;
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Lipopolysaccharide-Induced Leukocyte Rolling and Adhesion in the Rat Mesenteric Microcirculation: Regulation by Glucocorticoids and Role of Cytokines
Kelly L. Davenpeck, John Zagorski, Robert P. Schleimer and Bruce S. Bochner

J Immunol December 15, 1998, 161 (12) 6861-6870;
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The Type II IL-1 Receptor Interacts with the IL-1 Receptor Accessory Protein: A Novel Mechanism of Regulation of IL-1 Responsiveness
Detlef Lang, Johannes Knop, Holger Wesche, Ute Raffetseder, Roland Kurrle, Diana Boraschi and Michael U. Martin

J Immunol December 15, 1998, 161 (12) 6871-6877;
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Intrinsic Defects in Macrophage IL-12 Production Associated with Immune Dysfunction in the MRL/++ and New Zealand Black/White F₁ Lupus-Prone Mice and the Leishmania major-Susceptible BALB/c Strain
David G. Alleva, Steven B. Kaser and David I. Beller

J Immunol December 15, 1998, 161 (12) 6878-6884;
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Isolation and Characterization of a Variant HL60 Cell Line Defective in the Activation of the NADPH Oxidase by Phorbol Myristate Acetate
Marianne Tardif, Marie-Josèphe Rabiet, Thierry Christophe, Marie-Danielle Milcent and François Boulay

J Immunol December 15, 1998, 161 (12) 6885-6895;
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Astrocyte-Derived Monocyte-Chemoattractant Protein-1 Directs the Transmigration of Leukocytes Across a Model of the Human Blood-Brain Barrier
Jonathan M. Weiss, Sherry A. Downie, William D. Lyman and Joan W. Berman

J Immunol December 15, 1998, 161 (12) 6896-6903;
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Successful Induction of Adjuvant Arthritis in Mice by Treatment with a Monoclonal Antibody Against IL-4
Shin Yoshino, Yuzo Murata and Motoyasu Ohsawa

J Immunol December 15, 1998, 161 (12) 6904-6908;
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Antineutrophil Cytoplasmic Antibodies Preferentially Engage FcγRIIIb on Human Neutrophils
Markus Kocher, Jeffrey C. Edberg, Howard B. Fleit and Robert P. Kimberly

J Immunol December 15, 1998, 161 (12) 6909-6914;
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IL-4 Inhibits Mouse Mast Cell FcεRI Expression Through a STAT6-Dependent Mechanism
John J. Ryan, Shirley DeSimone, Gregory Klisch, Christopher Shelburne, Lisa J. McReynolds, Kathy Han, Reka Kovacs, Paria Mirmonsef and Thomas F. Huff

J Immunol December 15, 1998, 161 (12) 6915-6923;
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The First Subcomponent of Complement, C1q, Triggers the Production of IL-8, IL-6, and Monocyte Chemoattractant Peptide-1 by Human Umbilical Vein Endothelial Cells
Rocco H. van den Berg, Maria C. Faber-Krol, Robert B. Sim and Mohamed R. Daha

J Immunol December 15, 1998, 161 (12) 6924-6930;
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The Role of Adhesion Molecules in Human Leukocyte Attachment to Porcine Vascular Endothelium: Implications for Xenotransplantation
Lisa A. Robinson, LiLi Tu, Douglas A. Steeber, Ori Preis, Jeffrey L. Platt and Thomas F. Tedder

J Immunol December 15, 1998, 161 (12) 6931-6938;
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Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- But Not Perforin-Dependent Cytotoxicity or Cytokine Production
Benedikt Kessler, Denis Hudrisier, Michael Schroeter, Jürg Tschopp, Jean-Charles Cerottini and Immanuel F. Luescher

J Immunol December 15, 1998, 161 (12) 6939-6946;
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Activation of Phosphatidylinositol 3-Kinase, Protein Kinase B, and p70 S6 Kinases in Lipopolysaccharide-Stimulated Raw 264.7 Cells: Differential Effects of Rapamycin, Ly294002, and Wortmannin on Nitric Oxide Production
B. Salh, R. Wagey, A. Marotta, J. S. Tao and S. Pelech

J Immunol December 15, 1998, 161 (12) 6947-6954;

CLINICAL IMMUNOLOGY

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Diversity of the Fine Specificity Displayed by HLA-A*0201-Restricted CTL Specific for the Immunodominant Melan-A/MART-1 Antigenic Peptide
Danila Valmori, Nadine Gervois, Donata Rimoldi, Jean-Francois Fonteneau, Anilza Bonelo, Danielle Liénard, Licia Rivoltini, Francine Jotereau, Jean-Charles Cerottini and Pedro Romero

J Immunol December 15, 1998, 161 (12) 6956-6962;
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Early Development and Spreading of Autoantibodies to Epitopes of IA-2 and Their Association with Progression to Type 1 Diabetes
Heike E. Naserke, Anette-G. Ziegler, Vito Lampasona and Ezio Bonifacio

J Immunol December 15, 1998, 161 (12) 6963-6969;
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HLA-Independent Heterogeneity of CD8⁺ T Cell Responses to MAGE-3, Melan-A/MART-1, gp100, Tyrosinase, MC1R, and TRP-2 in Vaccine-Treated Melanoma Patients
Sandra R. Reynolds, Esteban Celis, Alessandro Sette, Ruth Oratz, Richard L. Shapiro, Dean Johnston, Marilena Fotino and Jean-Claude Bystryn

J Immunol December 15, 1998, 161 (12) 6970-6976;
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Combination Chemotherapy and IL-15 Administration Induce Permanent Tumor Regression in a Mouse Lung Tumor Model: NK and T Cell-Mediated Effects Antagonized by B Cells
Andrei I. Chapoval, Jane A. Fuller, Sergey G. Kremlev, Sonya J. Kamdar and Robert Evans

J Immunol December 15, 1998, 161 (12) 6977-6984;
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Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles
Yutaka Kawakami, Paul F. Robbins, Xiang Wang, Janis P. Tupesis, Maria R. Parkhurst, Xiaoqiang Kang, Kazuyasu Sakaguchi, Ettore Appella and Steven A. Rosenberg

J Immunol December 15, 1998, 161 (12) 6985-6992;
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Persistent Expression of Experimental Autoimmune Encephalomyelitis (EAE)-Specific Vβ8.2 TCR Spectratype in the Central Nervous System of Rats with Chronic Relapsing EAE
Giok Kim, Kuniko Kohyama, Naoyuki Tanuma, Hirohiko Arimito and Yoh Matsumoto

J Immunol December 15, 1998, 161 (12) 6993-6998;
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Genetic Determinants of Autoimmune Disease and Coronary Vasculitis in the MRL-lpr/lpr Mouse Model of Systemic Lupus Erythematosus
Lingjie Gu, Ari Weinreb, Xu-Ping Wang, Debra J. Zack, Jian-Hua Qiao, Richard Weisbart and Aldons J. Lusis

J Immunol December 15, 1998, 161 (12) 6999-7006;
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Environmental Antigen-Induced IL-13 Responses Are Elevated Among Subjects with Allergic Rhinitis, Are Independent of IL-4, and Are Inhibited by Endogenous IFN-γ Synthesis
Yan Li, F. Estelle R. Simons and Kent T. HayGlass

J Immunol December 15, 1998, 161 (12) 7007-7014;
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Prevention of Experimental Allergic Encephalomyelitis via Inhibition of IL-12 Signaling and IL-12-Mediated Th1 Differentiation: An Effect of the Novel Anti-Inflammatory Drug Lisofylline
John J. Bright, Caigan Du, Michael Coon, Subramaniam Sriram and Stephen J. Klaus

J Immunol December 15, 1998, 161 (12) 7015-7022;
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Terminal Deoxynucleotidyl Transferase Deficiency Reduces the Incidence of Autoimmune Nephritis in (New Zealand Black × New Zealand White)F₁ Mice
Carmen Conde, Sandra Weller, Susan Gilfillan, Luc Marcellin, Thierry Martin and Jean-Louis Pasquali

J Immunol December 15, 1998, 161 (12) 7023-7030;
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Molecular and Immunologic Characterization of a Highly Cross-Reactive Two EF-Hand Calcium-Binding Alder Pollen Allergen, Aln g 4: Structural Basis for Calcium-Modulated IgE Recognition
Brigitte Hayek, Luca Vangelista, Annalisa Pastore, Wolfgang R. Sperr, Peter Valent, Susanne Vrtala, Verena Niederberger, Anna Twardosz, Dietrich Kraft and Rudolf Valenta

J Immunol December 15, 1998, 161 (12) 7031-7039;
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Characterization of the Pathogenic Autoreactive T Cells in Cyclosporine-Induced Syngeneic Graft-Versus-Host Disease
Weiran Chen, Christopher Thoburn and Allan D. Hess

J Immunol December 15, 1998, 161 (12) 7040-7046;
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Temporal Role of Chemokines in a Murine Model of Cockroach Allergen-Induced Airway Hyperreactivity and Eosinophilia
Emma M. Campbell, Steven L. Kunkel, Robert M. Strieter and Nicholas W. Lukacs

J Immunol December 15, 1998, 161 (12) 7047-7053;
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Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice
David Broide, Jurgan Schwarze, Helen Tighe, Tim Gifford, Minh-Duc Nguyen, Siamak Malek, John Van Uden, Elena Martin-Orozco, Erwin W. Gelfand and Eyal Raz

J Immunol December 15, 1998, 161 (12) 7054-7062;
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Perforin/Fas-Ligand Double Deficiency Is Associated with Macrophage Expansion and Severe Pancreatitis
Julie Spielman, Richard K. Lee and Eckhard R. Podack

J Immunol December 15, 1998, 161 (12) 7063-7070;

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Table of Contents

EDITORIALS

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

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