The Journal of Immunology: 160 (4)

February 15, 1998; Volume 160,Issue 4

CUTTING EDGE

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Cutting Edge: Lyn-Mediated Down-Regulation of B Cell Antigen Receptor Signaling: Inhibition of Protein Kinase C Activation by Lyn in a Kinase-Independent Fashion
Hitoshi Katsuta, Sachiyo Tsuji, Yoshiyuki Niho, Tomohiro Kurosaki and Daisuke Kitamura

J Immunol February 15, 1998, 160 (4) 1547-1551;
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Cutting Edge: The Chicken TCR ζ-Chain Restores the Function of a Mouse T Cell Hybridoma
Thomas W. F. Göbel and Luca Bolliger

J Immunol February 15, 1998, 160 (4) 1552-1554;

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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Antigen Presentation by Dendritic Cells Focuses T Cell Responses Against Immunodominant Peptides: Studies in the Hen Egg-White Lysozyme (HEL) Model¹
Laurent Gapin, Yolanda Bravo de Alba, Armanda Casrouge, Jean Pierre Cabaniols, Philippe Kourilsky and Jean Kanellopoulos

J Immunol February 15, 1998, 160 (4) 1555-1564;
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Cross-Linking CD21/CD35 or CD19 Increases Both B7-1 and B7-2 Expression on Murine Splenic B Cells
Yuko Kozono, Ryo Abe, Haruo Kozono, Robert G. Kelly, Takachika Azuma and V. Michael Holers

J Immunol February 15, 1998, 160 (4) 1565-1572;
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NK Cell Natural Cytotoxicity and IFN-γ Production Are Not Always Coordinately Regulated: Engagement of DX9 KIR⁺ NK Cells by HLA-B7 Variants and Target Cells
Zoya B. Kurago, Charles T. Lutz, Kelly D. Smith and Marco Colonna

J Immunol February 15, 1998, 160 (4) 1573-1580;
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Inhibition of JAK3 and STAT6 Tyrosine Phosphorylation by the Immunosuppressive Drug Leflunomide Leads to a Block in IgG1 Production
Karyn Siemasko, Anita S-F. Chong, Hans-Martin Jäck, Haihua Gong, James W. Williams and Alison Finnegan

J Immunol February 15, 1998, 160 (4) 1581-1588;
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TGF-β Promotes Immune Deviation by Altering Accessory Signals of Antigen-Presenting Cells
Masaru Takeuchi, Pascale Alard and J. Wayne Streilein

J Immunol February 15, 1998, 160 (4) 1589-1597;
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Creating CTL Targets with Epitope-Linked β₂-Microglobulin Constructs
Robert A. Uger and Brian H. Barber

J Immunol February 15, 1998, 160 (4) 1598-1605;
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Non-MHC-Restricted Cell-Mediated Lysis of Human Oligodendrocytes In Vitro: Relation with CD56 Expression
Jack P. Antel, Ellie McCrea, Uma Ladiwala, Yu-fen Qin and Burkhard Becher

J Immunol February 15, 1998, 160 (4) 1606-1611;
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IL-12 Down-Regulates Autoantibody Production in Mercury-Induced Autoimmunity
Lee M. Bagenstose, Padmini Salgame and Marc Monestier

J Immunol February 15, 1998, 160 (4) 1612-1617;
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Participation of the CD94 Receptor Complex in Costimulation of Human Natural Killer Cells
Stephan D. Voss, John Daley, Jerome Ritz and Michael J. Robertson

J Immunol February 15, 1998, 160 (4) 1618-1626;
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Increased Apoptosis of T Cell Subsets in Aging Humans: Altered Expression of Fas (CD95), Fas Ligand, Bcl-2, and Bax
Sudeepta Aggarwal and Sudhir Gupta

J Immunol February 15, 1998, 160 (4) 1627-1637;
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IL-12 Receptor (IL-12R) Expression and Accumulation of IL-12Rβ1 and IL-12Rβ2 mRNAs in CD4⁺ T Cells by Costimulation with B7-2 Molecules
Osamu Igarashi, Hidehiro Yamane, Shinobu Imajoh-Ohmi and Hideo Nariuchi

J Immunol February 15, 1998, 160 (4) 1638-1646;
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Fcε Receptor I-Associated lyn-Dependent Phosphorylation of Fcγ Receptor IIB During Negative Regulation of Mast Cell Activation
Odile Malbec, Dana C. Fong, Martin Turner, Victor L. J. Tybulewicz, John C. Cambier, Wolf H. Fridman and Marc Daëron

J Immunol February 15, 1998, 160 (4) 1647-1658;
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The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation
Blandine de Saint-Vis, Isabelle Fugier-Vivier, Catherine Massacrier, Claude Gaillard, Béatrice Vanbervliet, Smina Aït-Yahia, Jacques Banchereau, Yong-Jun Liu, Serge Lebecque and Christophe Caux

J Immunol February 15, 1998, 160 (4) 1666-1676;
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Bispecific Molecules Directed to the Fc Receptor for IgA (FcαRI, CD89) and Tumor Antigens Efficiently Promote Cell-Mediated Cytotoxicity of Tumor Targets in Whole Blood
Yashwant M. Deo, Karuna Sundarapandiyan, Tibor Keler, Paul K. Wallace and Robert F. Graziano

J Immunol February 15, 1998, 160 (4) 1677-1686;
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Lack of Orally Induced Systemic Unresponsiveness in IFN-γ Knockout Mice
Mi-Na Kweon, Kohtaro Fujihashi, John L. VanCott, Kazuo Higuchi, Masafumi Yamamoto, Jerry R. McGhee and Hiroshi Kiyono

J Immunol February 15, 1998, 160 (4) 1687-1693;
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Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help
Anne E. Macaulay, Rosemarie H. DeKruyff and Dale T. Umetsu

J Immunol February 15, 1998, 160 (4) 1694-1700;
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CD40 Ligand/CD40 Stimulation Regulates the Production of IFN-γ from Human Peripheral Blood Mononuclear Cells in an IL-12- and/or CD28-Dependent Manner
John F. McDyer, Theresa J. Goletz, Elaine Thomas, Carl H. June and Robert A. Seder

J Immunol February 15, 1998, 160 (4) 1701-1707;
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IL-1α and TNF-α Are Required for IL-12-Induced Development of Th1 Cells Producing High Levels of IFN-γ in BALB/c But Not C57BL/6 Mice
Kazuko Shibuya, Douglas Robinson, Francesca Zonin, Suzanne B. Hartley, Steven E. Macatonia, Chamorro Somoza, Christopher A. Hunter, Kenneth M. Murphy and Anne O’Garra

J Immunol February 15, 1998, 160 (4) 1708-1716;
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Delivery of Multiple CD8 Cytotoxic T Cell Epitopes by DNA Vaccination
Scott A. Thomson, Martina A. Sherritt, Jill Medveczky, Suzanne L. Elliott, Denis J. Moss, Germain J. P. Fernando, Lorena E. Brown and Andreas Suhrbier

J Immunol February 15, 1998, 160 (4) 1717-1723;
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Resistance to Polyoma Virus-Induced Tumors Correlates with CTL Recognition of an Immunodominant H-2D^k-Restricted Epitope in the Middle T Protein
Aron E. Lukacher and Christopher S. Wilson

J Immunol February 15, 1998, 160 (4) 1724-1734;
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Early Intrathymic Precursor Cells Acquire a CD4^low Phenotype
Alison M. Michie, James R. Carlyle and Juan Carlos Zúñiga-Pflücker

J Immunol February 15, 1998, 160 (4) 1735-1741;
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IFN-γ-Inducing Factor/IL-18 Administration Mediates IFN-γ- and IL-12-Independent Antitumor Effects
Tadashi Osaki, Jean-Marie Péron, Quan Cai, Haruki Okamura, Paul D. Robbins, Masashi Kurimoto, Michael T. Lotze and Hideaki Tahara

J Immunol February 15, 1998, 160 (4) 1742-1749;
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Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues
Danila Valmori, Jean-François Fonteneau, Concepción Marañón Lizana, Nadine Gervois, Danielle Liénard, Donata Rimoldi, Victor Jongeneel, Francine Jotereau, Jean-Charles Cerottini and Pedro Romero

J Immunol February 15, 1998, 160 (4) 1750-1758;
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Immunodominance Does Not Result from Peptide Competition for MHC Class II Presentation
Richard Lo-Man, Jan P. M. Langeveld, Pierre Martineau, Maurice Hofnung, Robert H. Meloen and Claude Leclerc

J Immunol February 15, 1998, 160 (4) 1759-1766;
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A Tyrosine-Based Signal Present in Ig α Mediates B Cell Receptor Constitutive Internalization
Sylvanie Cassard, Jean Salamero, Daniel Hanau, Daniele Spehner, Jean Davoust, Wolf Herman Fridman and Christian Bonnerot

J Immunol February 15, 1998, 160 (4) 1767-1773;
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Dendritic Cells and Resting B Cells Form Clusters In Vitro and In Vivo: T Cell Independence, Partial LFA-1 Dependence, and Regulation by Cross-Linking Surface Molecules
Natalyia Kushnir, LiMing Liu and G. Gordon MacPherson

J Immunol February 15, 1998, 160 (4) 1774-1781;

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Flow-Microfluorometric Monitoring of Oligoclonal CD8⁺ T Cell Responses to an Immunodominant Moloney Leukemia Virus-Encoded Epitope In Vivo
Pierre Brawand, Giovanni Biasi, Clotilde Horvath, Jean-Charles Cerottini and H. Robson MacDonald

J Immunol February 15, 1998, 160 (4) 1659-1665;

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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Structure-Function Study of the Extracellular Domain of the Human IFN-α Receptor (hIFNAR1) Using Blocking Monoclonal Antibodies: The Role of Domains 1 and 2
Ji Lu, Anan Chuntharapai, Joanne Beck, Steve Bass, Arlene Ow, Abraham M. De Vos, Verna Gibbs and K. Jin Kim

J Immunol February 15, 1998, 160 (4) 1782-1788;
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Pentoxifylline Inhibits Ig κ Gene Transcription and Rearrangements in Pre-B Cells
Weihong Wang, Satyajit Rath, Jeannine M. Durdik and Ranjan Sen

J Immunol February 15, 1998, 160 (4) 1789-1795;

HOST DEFENSE

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Effects of Aminoguanidine on Latent Murine Tuberculosis
JoAnne L. Flynn, Charles A. Scanga, Kathryn E. Tanaka and John Chan2

J Immunol February 15, 1998, 160 (4) 1796-1803;
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Identification of a T Cell Subset Capable of both IFN-γ and IL-10 Secretion in Patients with Chronic Borrelia burgdorferi Infection
Annette Pohl-Koppe, Konstantin E. Balashov, Allen C. Steere, Eric L. Logigian and David A. Hafler

J Immunol February 15, 1998, 160 (4) 1804-1810;
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The Vasoactive Peptide Maxadilan from Sand Fly Saliva Inhibits TNF-α and Induces IL-6 by Mouse Macrophages Through Interaction with the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor
Milena B. P. Soares, Richard G. Titus, Charles B. Shoemaker, John R. David and Marcelo Bozza

J Immunol February 15, 1998, 160 (4) 1811-1816;
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Amastigote Surface Proteins of Trypanosoma cruzi Are Targets for CD8⁺ CTL
Hoi Pang Low, Maria A. M. Santos, Benjamin Wizel and Rick L. Tarleton

J Immunol February 15, 1998, 160 (4) 1817-1823;
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Toxoplasma gondii-Infected Cells Are Resistant to Multiple Inducers of Apoptosis
Paul B. Nash, Matthew B. Purner, Ronald P. Leon, Penelope Clarke, Richard C. Duke and Tyler J. Curiel

J Immunol February 15, 1998, 160 (4) 1824-1830;
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Role of CD80 (B7.1) and CD86 (B7.2) in the Immune Response to an Intracellular Pathogen
Carlos S. Subauste, Rene de Waal Malefyt and Franklin Fuh

J Immunol February 15, 1998, 160 (4) 1831-1840;
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Superantigen-Activated T Cells Redirected by a Bispecific Antibody Inhibit Vesicular Stomatitis Virus Replication In Vitro and In Vivo
Ana Fernandez-Sesma, Richard W. Peluso, Xu Bai, Jerome L. Schulman, David E. Levy and Thomas M. Moran

J Immunol February 15, 1998, 160 (4) 1841-1849;
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Th2 Cells Are Required for the Schistosoma mansoni Egg-Induced Granulomatous Response
Mark H. Kaplan, Joel R. Whitfield, Dov L. Boros and Michael J. Grusby

J Immunol February 15, 1998, 160 (4) 1850-1856;
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Leishmania Lipophosphoglycan Reduces Monocyte Transendothelial Migration: Modulation of Cell Adhesion Molecules, Intercellular Junctional Proteins, and Chemoattractants
Siu K. Lo, Lisa Bovis, Rosemarie Matura, Baixin Zhu, Suhui He, Hazel Lum, Salvatore J. Turco and John L. Ho

J Immunol February 15, 1998, 160 (4) 1857-1865;
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Importance of the B7-2 Molecule for Low Dose Melphalan-Induced Acquisition of Tumor-Eradicating Immunity by Mice Bearing a Large MOPC-315 Tumor
Margalit B. Mokyr, Tatiana V. Kalinichenko, Leonid Gorelik and Jeffrey A. Bluestone

J Immunol February 15, 1998, 160 (4) 1866-1874;
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Involvement of Extracellular Signal-Regulated Kinase Module in HIV-Mediated CD4 Signals Controlling Activation of Nuclear Factor-κB and AP-1 Transcription Factors
Laurence Briant, Véronique Robert-Hebmann, Virginie Sivan, Anne Brunet, Jacques Pouysségur and Christian Devaux

J Immunol February 15, 1998, 160 (4) 1875-1885;

INFLAMMATION

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Morphine Enhances Macrophage Apoptosis
Pravin C. Singhal, Puneet Sharma, Aditi A. Kapasi, Krishna Reddy, Nicholas Franki and Nora Gibbons

J Immunol February 15, 1998, 160 (4) 1886-1893;
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RANTES Activation of Phospholipase D in Jurkat T Cells: Requirement of GTP-Binding Proteins ARF and RhoA
Kevin B. Bacon, Thomas J. Schall and Daniel J. Dairaghi

J Immunol February 15, 1998, 160 (4) 1894-1900;
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Phosphatidylinositol 3-Kinase Mediates Chemoattractant-Stimulated, CD11b/CD18-Dependent Cell-Cell Adhesion of Human Neutrophils: Evidence for an ERK-Independent Pathway
Constance Capodici, Simon Hanft, Marianne Feoktistov and Michael H. Pillinger

J Immunol February 15, 1998, 160 (4) 1901-1909;
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Induction of a Selective and Persistent Extravasation of Neutrophils into the Peritoneal Cavity by Tryptase Mouse Mast Cell Protease 6
Chifu Huang, Daniel S. Friend, Wen-Tao Qiu, Guang W. Wong, Guillermo Morales, John Hunt and Richard L. Stevens

J Immunol February 15, 1998, 160 (4) 1910-1919;
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CD14-Dependent Internalization of Bacterial Lipopolysaccharide (LPS) Is Strongly Influenced by LPS Aggregation But Not by Cellular Responses to LPS
Richard L. Kitchens and Robert S. Munford

J Immunol February 15, 1998, 160 (4) 1920-1928;
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C1qR_P, the C1q Receptor That Enhances Phagocytosis, Is Detected Specifically in Human Cells of Myeloid Lineage, Endothelial Cells, and Platelets
Ronald R. Nepomuceno and Andrea J. Tenner

J Immunol February 15, 1998, 160 (4) 1929-1935;
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High Dose Intravenous Immunoglobulin Does Not Affect Complement-Bacteria Interactions
Eric Wagner, Jeffrey L. Platt and Michael M. Frank2

J Immunol February 15, 1998, 160 (4) 1936-1943;
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Cytokine Regulation of Human Microglial Cell IL-8 Production
Laura C. Ehrlich, Shuxian Hu, Wen S. Sheng, Richard L. Sutton, Gaylan L. Rockswold, Phillip K. Peterson and Chun C. Chao

J Immunol February 15, 1998, 160 (4) 1944-1948;
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The Glycosyl-Inositol-Phosphate and Dimyristoylglycerol Moieties of the Glycosylphosphatidylinositol Anchor of the Trypanosome Variant-Specific Surface Glycoprotein Are Distinct Macrophage-Activating Factors
Stefan Magez, Benoı̂t Stijlemans, Magdalena Radwanska, Etienne Pays, Michael A. J. Ferguson and Patrick De Baetselier

J Immunol February 15, 1998, 160 (4) 1949-1956;
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Differential Regulation of IL-4 and IL-13 Secretion by Human Basophils: Their Relationship to Histamine Release in Mixed Leukocyte Cultures
Angela C. Redrup, Brian P. Howard, Donald W. MacGlashan Jr., Anne Kagey-Sobotka, Lawrence M. Lichtenstein and John T. Schroeder

J Immunol February 15, 1998, 160 (4) 1957-1964;
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Primary γδ Cell Clones Can Be Defined Phenotypically and Functionally as Th1/Th2 Cells and Illustrate the Association of CD4 with Th2 Differentiation
Li Wen, Domingo F. Barber, William Pao, F. Susan Wong, Michael J. Owen and Adrian Hayday

J Immunol February 15, 1998, 160 (4) 1965-1974;
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Identification of CCR8 as the Specific Receptor for the Human β-Chemokine I-309: Cloning and Molecular Characterization of Murine CCR8 as the Receptor for TCA-3
Iñigo Goya, Julio Gutiérrez, Rosa Varona, Leonor Kremer, Angel Zaballos and Gabriel Márquez

J Immunol February 15, 1998, 160 (4) 1975-1981;
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p38 Mitogen-Activated Protein Kinase Activation Is Required for Human Neutrophil Function Triggered by TNF-α or FMLP Stimulation
You-Li Zu, Jiafan Qi, Annette Gilchrist, Gustavo A. Fernandez, Dolores Vazquez-Abad, Donald L. Kreutzer, Chi-Kuang Huang and Ramadan I. Sha’afi

J Immunol February 15, 1998, 160 (4) 1982-1989;

CLINICAL IMMUNOLOGY

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High Levels of TNF, Soluble TNF Receptors, Soluble ICAM-1, and IFN-γ, but Low Levels of IL-5, Are Associated with Hepatosplenic Disease in Human Schistosomiasis Mansoni
Joseph K. Mwatha, Gachuhi Kimani, Timothy Kamau, Gabriel G. Mbugua, John H. Ouma, Jasper Mumo, Anthony J. C. Fulford, Frances M. Jones, Anthony E. Butterworth, Morven B. Roberts and David W. Dunne

J Immunol February 15, 1998, 160 (4) 1992-1999;
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HIV-1 Neutralizing Antibodies in the Genital and Respiratory Tracts of Mice Intranasally Immunized with Oligomeric gp160
Thomas C. VanCott, Robert W. Kaminski, John R. Mascola, Vaniambadi S. Kalyanaraman, Nabila M. Wassef, Carl R. Alving, J.Terry Ulrich, George H. Lowell and Deborah L. Birx

J Immunol February 15, 1998, 160 (4) 2000-2012;
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The Secreted Hepatitis B Precore Antigen Can Modulate the Immune Response to the Nucleocapsid: A Mechanism for Persistence
David R. Milich, Margaret K. Chen, Janice L. Hughes and Joyce E. Jones

J Immunol February 15, 1998, 160 (4) 2013-2021;
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Long-Lived Th2 Clones Specific for Seasonal and Perennial Allergens Can Be Detected in Blood and Skin by Their TCR-Hypervariable Regions
Barbara Bohle, Herwig Schwihla, Huai-Zhong Hu, Roswitha Friedl-Hajek, Slawomir Sowka, Fátima Ferreira, Heimo Breiteneder, Carla A. F. M. Bruijnzeel-Koomen, Roel A. de Weger, Geert C. Mudde, Christof Ebner and Frank C. Van Reijsen

J Immunol February 15, 1998, 160 (4) 2022-2027;

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Table of Contents

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

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