A Critical Role for IL-18 in the Proliferation and Activation of NK1.1+CD3− Cells

Michio Tomura; Xu-Yu Zhou; Seiji Maruo; Hyun-Jong Ahn; Toshiyuki Hamaoka; Haruki Okamura; Kenji Nakanishi; Tadao Tanimoto; Masashi Kurimoto; Hiromi Fujiwara

Article Information

vol. 160 no. 10 4738-4746

PubMed

9590219

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Received October 3, 1997
Accepted January 14, 1998
Published online May 15, 1998.

Author Information

Michio Tomura^*,
Xu-Yu Zhou^*,
Seiji Maruo^*,
Hyun-Jong Ahn^*,
Toshiyuki Hamaoka^*,
Haruki Okamura^†,
Kenji Nakanishi^‡,
Tadao Tanimoto^§,
Masashi Kurimoto^§ and
Hiromi Fujiwara²,^*

^*Biomedical Research Center, Osaka University Medical School, Yamada-oka, Suita, Osaka, Japan; Departments of
^†Bacteriology and
^‡Immunology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; and
^§Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan

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	Abstract	Full	Pdf
Sep 2000	0	1	0
Oct 2000	0	4	4
Nov 2000	0	7	10
Dec 2000	1	4	1
Total 2000	1	16	15
Jan 2001	3	8	10
Feb 2001	0	1	2
Mar 2001	2	9	4
Apr 2001	3	7	5
May 2001	0	2	8
Jun 2001	1	11	11
Jul 2001	0	3	2
Aug 2001	0	6	9
Sep 2001	1	7	7
Oct 2001	8	6	3
Nov 2001	2	8	7
Dec 2001	3	7	5
Total 2001	23	75	73
Jan 2002	1	8	10
Feb 2002	0	2	1
Mar 2002	1	7	7
Apr 2002	2	1	5
May 2002	0	5	7
Jun 2002	0	3	5
Jul 2002	0	4	3
Aug 2002	0	4	5
Sep 2002	2	8	7
Oct 2002	0	2	3
Nov 2002	2	6	3
Dec 2002	2	5	9
Total 2002	10	55	65
Jan 2003	3	9	7
Feb 2003	1	0	1
Mar 2003	2	4	2
Apr 2003	0	2	0
May 2003	3	5	2
Jun 2003	0	4	6
Jul 2003	164	9	7
Aug 2003	3	7	7
Sep 2003	7	10	2
Oct 2003	4	5	4
Nov 2003	7	13	10
Dec 2003	6	9	2
Total 2003	200	77	50
Jan 2004	7	5	5
Feb 2004	4	4	1
Mar 2004	3	8	7
Apr 2004	12	19	7
May 2004	7	10	9
Jun 2004	3	15	6
Jul 2004	10	12	7
Aug 2004	12	15	13
Sep 2004	6	5	7
Oct 2004	6	12	4
Nov 2004	11	9	3
Dec 2004	7	6	5
Total 2004	88	120	74
Jan 2005	8	11	5
Feb 2005	4	9	1
Mar 2005	11	11	2
Apr 2005	2	3	0
May 2005	6	11	10
Jun 2005	1	6	5
Jul 2005	2	6	6
Aug 2005	6	7	4
Sep 2005	1	1	0
Oct 2005	0	5	4
Nov 2005	3	7	2
Dec 2005	3	8	1
Total 2005	47	85	40
Jan 2006	1	4	3
Feb 2006	3	9	3
Mar 2006	1	7	5
Apr 2006	1	3	3
May 2006	5	6	4
Jun 2006	0	6	1
Jul 2006	3	2	1
Aug 2006	2	2	0
Sep 2006	0	5	1
Oct 2006	2	0	3
Nov 2006	8	12	3
Dec 2006	27	28	9
Total 2006	53	84	36
Jan 2007	18	21	2
Feb 2007	23	29	3
Mar 2007	15	16	1
Apr 2007	0	7	2
May 2007	1	2	1
Jun 2007	4	3	1
Jul 2007	7	14	4
Aug 2007	3	5	6
Sep 2007	3	5	2
Oct 2007	1	3	5
Nov 2007	2	3	6
Dec 2007	0	3	2
Total 2007	77	111	35
Jan 2008	2	2	2
Feb 2008	3	1	0
Mar 2008	1	2	3
Apr 2008	1	1	0
May 2008	2	0	1
Jun 2008	2	4	2
Jul 2008	1	6	7
Aug 2008	3	4	2
Sep 2008	2	4	3
Oct 2008	0	5	2
Nov 2008	1	3	2
Dec 2008	3	1	2
Total 2008	21	33	26
Jan 2009	1	2	3
Feb 2009	5	3	5
Mar 2009	1	5	6
Apr 2009	2	2	3
May 2009	1	1	3
Jun 2009	2	3	2
Jul 2009	0	3	2
Aug 2009	4	2	1
Sep 2009	3	5	4
Oct 2009	0	3	1
Nov 2009	3	5	4
Dec 2009	0	10	4
Total 2009	22	44	38
Jan 2010	3	2	3
Feb 2010	3	2	2
Mar 2010	4	3	3
Apr 2010	1	3	2
May 2010	6	1	1
Jun 2010	1	2	4
Jul 2010	1	4	2
Aug 2010	6	3	6
Sep 2010	4	2	4
Oct 2010	6	4	2
Nov 2010	2	3	2
Dec 2010	6	4	3
Total 2010	43	33	34
Jan 2011	4	5	2
Feb 2011	4	1	2
Mar 2011	4	8	3
Apr 2011	6	6	3
May 2011	7	10	3
Jun 2011	4	13	12
Jul 2011	11	3	9
Aug 2011	15	8	4
Sep 2011	15	7	7
Oct 2011	19	4	3
Nov 2011	31	6	4
Dec 2011	11	4	8
Total 2011	131	75	60
Jan 2012	23	2	4
Feb 2012	12	3	4
Mar 2012	26	3	7
Apr 2012	13	2	3
May 2012	15	4	7
Jun 2012	22	3	1
Jul 2012	17	4	6
Aug 2012	15	8	3
Sep 2012	22	3	2
Oct 2012	34	5	6
Nov 2012	21	4	4
Dec 2012	19	3	3
Total 2012	239	44	50
Jan 2013	29	10	13
Feb 2013	13	2	2
Mar 2013	25	3	18
Apr 2013	17	9	11
May 2013	30	2	11
Jun 2013	16	0	8
Jul 2013	14	0	4
Aug 2013	11	1	4
Sep 2013	25	4	7
Oct 2013	17	3	6
Nov 2013	9	9	2
Dec 2013	17	3	3
Total 2013	223	46	89
Jan 2014	13	0	0
Feb 2014	15	0	3
Mar 2014	8	4	5
Apr 2014	20	3	3
May 2014	27	2	5
Jun 2014	8	5	2
Jul 2014	18	8	8
Aug 2014	12	2	3
Sep 2014	11	1	3
Oct 2014	10	5	6
Nov 2014	21	3	3
Dec 2014	5	5	7
Total 2014	168	38	48
Jan 2015	7	4	6
Feb 2015	19	2	7
Mar 2015	16	1	5
Apr 2015	16	3	8
May 2015	16	8	11
Jun 2015	9	0	4
Jul 2015	10	9	9
Aug 2015	10	3	15
Sep 2015	14	2	0
Oct 2015	6	1	6
Nov 2015	8	5	8
Dec 2015	9	2	9
Total 2015	140	40	88
Jan 2016	12	10	10
Feb 2016	8	3	4
Mar 2016	18	3	9
Apr 2016	11	1	1
May 2016	8	2	3
Jun 2016	11	9	7
Jul 2016	7	5	7
Aug 2016	4	1	6
Sep 2016	11	1	3
Oct 2016	11	1	8
Nov 2016	2	1	0
Dec 2016	6	5	4
Total 2016	109	42	62
Jan 2017	2	4	11
Feb 2017	2	13	7
Mar 2017	0	3	5
Apr 2017	0	4	2
May 2017	1	1	1
Jun 2017	2	5	7
Jul 2017	0	2	4
Aug 2017	1	3	5
Sep 2017	5	6	2
Oct 2017	0	3	0
Nov 2017	0	7	4
Dec 2017	0	5	3
Total 2017	13	56	51
Jan 2018	3	7	1
Feb 2018	0	3	4
Mar 2018	3	5	0
Apr 2018	0	3	3
May 2018	2	8	6
Jun 2018	6	9	6
Jul 2018	0	7	1
Aug 2018	0	7	0
Sep 2018	0	9	2
Oct 2018	2	11	3
Nov 2018	1	12	8
Dec 2018	1	10	6
Total 2018	18	91	40
Jan 2019	1	5	1
Feb 2019	0	6	0
Mar 2019	0	15	7
Apr 2019	2	4	5
May 2019	2	1	5
Jun 2019	2	7	2
Jul 2019	4	5	2
Aug 2019	2	6	6
Sep 2019	0	7	1
Oct 2019	1	9	1
Nov 2019	2	10	2
Dec 2019	1	16	12
Total 2019	17	91	44
Total	1643	1256	1018