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The cytoplasmic domain of CD5 mediates both TCR/CD3-dependent and -independent diacylglycerol production.

M Simarro, C Pelassy, J Calvo, L Places, C Aussel and F Lozano
J Immunol November 1, 1997, 159 (9) 4307-4315;
M Simarro
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C Pelassy
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J Calvo
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L Places
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C Aussel
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F Lozano
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Abstract

CD5 is a 67-kDa surface glycoprotein found in association with the Ag receptor complex on both T and B lymphocytes. CD5 modulates Ag receptor-mediated immune responses, but the molecular mechanisms of its action remain unclear. In this respect, the assessment of the relative and unique contribution of CD5 in cell signaling events is a crucial point. We have used Jurkat variants and anti-CD5 mAbs to show that the CD5 signaling pathway is distinct from that used by the TCR/CD3 complex. We hereby identify two independent mechanisms of CD5-mediated diacylglycerol release by virtue of their different kinetics: 1) an early and transient diacylglycerol increase that results from the activation of a phosphatidylcholine-specific phospholipase C, and 2) a late and sustained increase that requires de novo phospholipid synthesis. Studies performed on a TCR/CD3-deficient Jurkat cell variant indicate that only the CD5-mediated phosphatidylcholine-specific phospholipase C activation is dependent on TCR/CD3 expression. Mutational analyses of CD5 demonstrate that both mechanisms are dependent on the integrity of the CD5 distal cytoplasmic region. Our results show that CD5 is a signaling molecule per se that uses mechanisms resembling those used by some cytokine receptors (such as IL-1 or TNF receptors) to modulate lymphocyte activation.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 159, Issue 9
1 Nov 1997
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The cytoplasmic domain of CD5 mediates both TCR/CD3-dependent and -independent diacylglycerol production.
M Simarro, C Pelassy, J Calvo, L Places, C Aussel, F Lozano
The Journal of Immunology November 1, 1997, 159 (9) 4307-4315;

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The cytoplasmic domain of CD5 mediates both TCR/CD3-dependent and -independent diacylglycerol production.
M Simarro, C Pelassy, J Calvo, L Places, C Aussel, F Lozano
The Journal of Immunology November 1, 1997, 159 (9) 4307-4315;
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Print ISSN 0022-1767        Online ISSN 1550-6606