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Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.

D I Daikh, B K Finck, P S Linsley, D Hollenbaugh and D Wofsy
J Immunol October 1, 1997, 159 (7) 3104-3108;
D I Daikh
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B K Finck
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P S Linsley
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D Hollenbaugh
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D Wofsy
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Abstract

Murine lupus in NZB/NZW F1 (B/W) mice can be retarded by sustained administration of CTLA4Ig and by brief treatment early in life with mAb that block CD40/gp39 interactions. We sought to determine whether brief therapy with CTLA4Ig could provide sustained benefit in B/W mice and whether a synergistic effect could be derived by blockade of both the B7/CD28 and the CD40/gp39 pathways. We found that a short course of CTLA4Ig at the onset of disease produced only short-term benefit. However, when CTLA4Ig was combined with anti-gp39, there was long-lasting inhibition of autoantibody production and renal disease. Ten months after the 2-wk course of therapy, 70% of these mice were alive, compared with only 18% and 0% of those that received only anti-gp39 or CTLA4Ig, respectively. These findings demonstrate that brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways can produce benefit that lasts long after treatment has been discontinued.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 159, Issue 7
1 Oct 1997
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Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
D I Daikh, B K Finck, P S Linsley, D Hollenbaugh, D Wofsy
The Journal of Immunology October 1, 1997, 159 (7) 3104-3108;

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Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
D I Daikh, B K Finck, P S Linsley, D Hollenbaugh, D Wofsy
The Journal of Immunology October 1, 1997, 159 (7) 3104-3108;
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Print ISSN 0022-1767        Online ISSN 1550-6606