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Regulation of Ku expression in normal murine B cells by stimuli that promote switch recombination.

P Zelazowski, E E Max, M R Kehry and C M Snapper
J Immunol September 15, 1997, 159 (6) 2559-2562;
P Zelazowski
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E E Max
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M R Kehry
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C M Snapper
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Abstract

DNA-dependent protein kinase, the catalytic subunit associated with the Ku heterodimer (Ku70/Ku86), has been implicated in switch recombination. Therefore, we tested whether certain stimuli known to promote switch recombination may act in part by inducing Ku expression. We find that resting B cells contain relatively low levels of nuclear Ku, but that Ku expression can be up-regulated by culturing the cells with two switch stimuli. First, IL-4 and CD40 engagement in combination, but neither of these stimuli acting alone, strongly induce Ku expression; Ku levels rise within 24 h, about 2 days before switch recombination is detected. Second, dextran-conjugated anti-IgD Abs strongly induce Ku expression, which is variably enhanced by IL-5, but not by IL-4. Our data suggest that switch recombination may be regulated, at least in part, through changes in the nuclear expression of Ku.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 159, Issue 6
15 Sep 1997
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Regulation of Ku expression in normal murine B cells by stimuli that promote switch recombination.
P Zelazowski, E E Max, M R Kehry, C M Snapper
The Journal of Immunology September 15, 1997, 159 (6) 2559-2562;

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Regulation of Ku expression in normal murine B cells by stimuli that promote switch recombination.
P Zelazowski, E E Max, M R Kehry, C M Snapper
The Journal of Immunology September 15, 1997, 159 (6) 2559-2562;
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Print ISSN 0022-1767        Online ISSN 1550-6606