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Calcitonin gene-related peptide is necessary for ultraviolet B-impaired induction of contact hypersensitivity.

H Niizeki, P Alard and J W Streilein
J Immunol December 1, 1997, 159 (11) 5183-5186;
H Niizeki
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P Alard
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J W Streilein
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Abstract

Since nerve termini on Langerhans cells (LC) contain calcitonin gene-related peptide (CGRP), and since ultraviolet B radiation (UVR) causes CGRP to be released from cutaneous nerve endings, we examined whether CGRP participates in the immune aberrations caused in skin by UVR. First, intradermally injected CGRP, in a dose-dependent manner, reduced LC density and impaired CH induction when hapten was painted on the injected site. Second, CGRP antagonist restored CH induction after UVR. Third, anti-TNF-alpha Abs injected before CGRP prevented the loss of LC density and restored CH induction. Fourth, CGRP failed to impair CH induction in mast cell-deficient mice. Fifth, CGRP induced mast cells to release TNF-alpha. We conclude that CGRP plays an essential role in the loss of CH induction after UVR. These data indicate that UVR, by causing the release of CGRP from cutaneous nerve endings, triggers mast cell release of TNF-alpha, which impairs CH induction.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 159, Issue 11
1 Dec 1997
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Calcitonin gene-related peptide is necessary for ultraviolet B-impaired induction of contact hypersensitivity.
H Niizeki, P Alard, J W Streilein
The Journal of Immunology December 1, 1997, 159 (11) 5183-5186;

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Calcitonin gene-related peptide is necessary for ultraviolet B-impaired induction of contact hypersensitivity.
H Niizeki, P Alard, J W Streilein
The Journal of Immunology December 1, 1997, 159 (11) 5183-5186;
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Print ISSN 0022-1767        Online ISSN 1550-6606