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SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis.

A Satoskar, F Brombacher, W J Dai, I McInnes, F Y Liew, J Alexander and W Walker
J Immunol November 15, 1997, 159 (10) 5005-5013;
A Satoskar
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F Brombacher
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W J Dai
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I McInnes
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F Y Liew
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J Alexander
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W Walker
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Abstract

To characterize the roles of lymphoid- and non-lymphoid-derived IL-4 during cutaneous infection with Leishmania mexicana, the disease was monitored in SCID mice reconstituted with splenocytes from either immunocompetent BALB/c mice or IL-4-deficient BALB/c mice. Whereas following s.c. infection with L. mexicana no lesion growth was observed in BALB/c IL-4(-/-) mice and lesion growth was significantly inhibited in SCID mice, rapid initial lesion growth occurred in both SCID IL-4(+/+) and SCID IL-4(-/-) reconstituted mice. However, after 3 to 4 wk of infection, lesions in SCID IL-4(-/-) but not SCID IL-4(+/+) reconstituted mice began to heal. This paralleled a developing Th1-like phenotype and parasite clearance in the former group and a developing Th2-like phenotype in the latter group. Lesion sites from the healing SCID IL-4(-/-) mice expressed the inducible nitric oxide synthase, whereas the SCID IL-4(+/+) mice with progressive disease did not. These findings indicate that non-lymphocyte-derived IL-4 may play a role in initiating lesion growth following cutaneous infection with L. mexicana, but the presence of lymphocyte-derived IL-4 is essential for disease progression, and in its absence, lesions heal due to a developing Th1 phenotype.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 159, Issue 10
15 Nov 1997
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SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis.
A Satoskar, F Brombacher, W J Dai, I McInnes, F Y Liew, J Alexander, W Walker
The Journal of Immunology November 15, 1997, 159 (10) 5005-5013;

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SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis.
A Satoskar, F Brombacher, W J Dai, I McInnes, F Y Liew, J Alexander, W Walker
The Journal of Immunology November 15, 1997, 159 (10) 5005-5013;
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Print ISSN 0022-1767        Online ISSN 1550-6606