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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration.

D Pajkrt, L Camoglio, M C Tiel-van Buul, K de Bruin, D L Cutler, M B Affrime, G Rikken, T van der Poll, J W ten Cate and S J van Deventer
J Immunol April 15, 1997, 158 (8) 3971-3977;
D Pajkrt
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L Camoglio
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M C Tiel-van Buul
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K de Bruin
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D L Cutler
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M B Affrime
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G Rikken
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T van der Poll
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J W ten Cate
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S J van Deventer
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Abstract

To determine the effects of IL-10 on cytokine and granulocyte responses during endotoxemia, two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on two occasions, once in combination with placebo injection, and once in conjunction with i.v. administered recombinant human IL-10 (rhIL-10) (25 microg/kg). In group 1, rhIL-10 was administered 2 min before endotoxin challenge; in group 2, the intervention was delayed for 1 h after endotoxin administration. rhIL-10 pretreatment reduced the LPS-induced rises in temperature and release of TNF, IL-6, IL-8, and IL-1 receptor antagonist. Endotoxin-induced granulocyte accumulation in lungs, as determined by dynamic granuloscintigrams, was prevented by rhIL-10 pretreatment, whereas granulocyte recruitment in liver and spleen was only modestly reduced. In addition, granulocyte degranulation, as measured by plasma elastase/alpha1-antitrypsin complexes, was blunted significantly by rhIL-10 pretreatment. Post-treatment with rhIL-10 did not influence LPS-induced temperature responses, cytokine release, or granulocyte degranulation. Both rhIL-10 pretreatment and post-treatment reduced LPS-induced cortisol levels. These results indicate that pretreatment with rhIL-10 reduces endotoxin-induced febrile responses, cytokine responses, and granulocyte accumulation in lungs, while in this acute model post-treatment with rhIL-10 exerts limited anti-inflammatory effects.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 158, Issue 8
15 Apr 1997
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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration.
D Pajkrt, L Camoglio, M C Tiel-van Buul, K de Bruin, D L Cutler, M B Affrime, G Rikken, T van der Poll, J W ten Cate, S J van Deventer
The Journal of Immunology April 15, 1997, 158 (8) 3971-3977;

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Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration.
D Pajkrt, L Camoglio, M C Tiel-van Buul, K de Bruin, D L Cutler, M B Affrime, G Rikken, T van der Poll, J W ten Cate, S J van Deventer
The Journal of Immunology April 15, 1997, 158 (8) 3971-3977;
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Print ISSN 0022-1767        Online ISSN 1550-6606