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The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase.

X P Chen, E Y Enioutina and R A Daynes
J Immunol April 1, 1997, 158 (7) 3070-3080;
X P Chen
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E Y Enioutina
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R A Daynes
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Abstract

IL-4 is important in controlling the development of immune responses. Following activation with anti-CD3epsilon under serum-free conditions, splenocytes from most normal (neu-1b) mouse strains directly produced IL-4 and other T cell cytokines. However, splenic T cells from SM/J and B10.SM (H-2v, neu-1a) strain mice, deficient in neu-1 sialidase activity, failed to produce IL-4 but produced normal levels of IL-2 following activation. Moreover, sialidase-deficient mice produced markedly less IgE and IgG1 Abs following immunization with protein Ags than did mouse strains with normal neu-1 sialidase activity. Enriched T cells from neu-1a mice failed to be effectively primed with exogenous murine IL-4 to become IL-4-producing cells. Treatment of splenocytes or enriched T cells from neu-1a mice with bacterial sialidase prior to activation or IL-4 priming promoted their subsequent capacity to produce IL-4. In contrast, activation of T cells from neu-1b mice in the presence of a sialidase inhibitor almost completely blocked subsequent IL-4 production. The presence of IL-4 during priming enhanced T cell expression of neu-1-specific sialidase activity and increased the membrane expression of asialo-G(M1) compared with T cells activated without IL-4. These results suggest that T cell-associated neu-1 sialidase is required for early IL-4 production by splenic T cells and is involved in the IL-4 priming process of conventional T cells to become active IL-4 producers.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 158, Issue 7
1 Apr 1997
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The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase.
X P Chen, E Y Enioutina, R A Daynes
The Journal of Immunology April 1, 1997, 158 (7) 3070-3080;

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The control of IL-4 gene expression in activated murine T lymphocytes: a novel role for neu-1 sialidase.
X P Chen, E Y Enioutina, R A Daynes
The Journal of Immunology April 1, 1997, 158 (7) 3070-3080;
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Print ISSN 0022-1767        Online ISSN 1550-6606