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IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences.

N Polentarutti, P Allavena, G Bianchi, G Giardina, A Basile, S Sozzani, A Mantovani and M Introna
J Immunol March 15, 1997, 158 (6) 2689-2694;
N Polentarutti
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P Allavena
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G Bianchi
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G Giardina
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A Basile
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S Sozzani
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A Mantovani
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M Introna
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Abstract

NK cells migrate in response to C-C chemokines, including monocyte chemotactic protein-1 (MCP-1) and MCP-3. Increased migration was observed in IL-2-activated NK cells. It was therefore of interest to define the expression in resting and activated NK cells of the MCP-1 receptor (CCR2) for which two cDNAs (A and B) have been described. Specific oligonucleotides and reverse-transcriptase PCR revealed the presence in activated NK cells and mononuclear phagocytes of the fragments expected on the basis of the reported cDNAs. In addition, amplification with a common A/B- and an A-specific oligonucleotide yielded an unexpected, abundant, 1649-bp fragment. Sequence analysis as well as Northern blotting and RNase protection with different probes revealed that the CCR2 gene is expressed in activated NK cells and mononuclear phagocytes as a predominant long transcript (3.4 kb) consisting of CCR2B, followed by a novel sequence (X), corresponding to an intron in the genome, and by a CCR2A-specific portion. The predominant long transcript is polyadenylated and present in the cytoplasm. The augmented migratory capacity of IL-2 activated vs resting NK cells was associated with increased CCR2 transcript levels.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 158, Issue 6
15 Mar 1997
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IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences.
N Polentarutti, P Allavena, G Bianchi, G Giardina, A Basile, S Sozzani, A Mantovani, M Introna
The Journal of Immunology March 15, 1997, 158 (6) 2689-2694;

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IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences.
N Polentarutti, P Allavena, G Bianchi, G Giardina, A Basile, S Sozzani, A Mantovani, M Introna
The Journal of Immunology March 15, 1997, 158 (6) 2689-2694;
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Print ISSN 0022-1767        Online ISSN 1550-6606