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CD28 costimulation promotes the production of Th2 cytokines.

I C Rulifson, A I Sperling, P E Fields, F W Fitch and J A Bluestone
J Immunol January 15, 1997, 158 (2) 658-665;
I C Rulifson
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A I Sperling
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P E Fields
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F W Fitch
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J A Bluestone
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Abstract

CD28 ligation augments TCR-mediated proliferation, IL-2 production, and T cell survival. However, the role of CD28 costimulation in T cell differentiation remains controversial. To address this issue, CD28+ and CD28-deficient TCR alphabeta transgenic (Tg) mice were used to examine cytokine production by T cells following antigenic stimulation. Increasing CD28 ligation resulted in increased production of IL-4 and IL-5, consistent with differentiation toward a Th2 phenotype, in both CD4+ TCR Tg T cells and CD8+ TCR Tg T cells. The same result was obtained with CD4+ TCR Tg mice bred to RAG2-deficient mice, indicating that the Th2 differentiation observed with increased CD28 ligation was not due to the presence of memory T cells. Although CD28 costimulation is an essential factor regulating IL-2 synthesis, differentiation toward a Th2-like phenotype by CD28 ligation was not an indirect effect of enhanced IL-2 production. In contrast, blockade of IL-4 during the primary cultures of the T cells resulted in a profound inability to produce Th2-type cytokines upon restimulation. The critical role of IL-4 was confirmed by the finding that CD28-deficient TCR alphabeta Tg+ T cells cultured with rIL-4 differentiated into Th2-like T cells. Therefore, CD28 ligation promotes the production of Th2-type cytokines by naive murine T cells via an IL-4-dependent mechanism.

  • Copyright © 1997 by American Association of Immunologists

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The Journal of Immunology
Vol. 158, Issue 2
15 Jan 1997
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CD28 costimulation promotes the production of Th2 cytokines.
I C Rulifson, A I Sperling, P E Fields, F W Fitch, J A Bluestone
The Journal of Immunology January 15, 1997, 158 (2) 658-665;

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CD28 costimulation promotes the production of Th2 cytokines.
I C Rulifson, A I Sperling, P E Fields, F W Fitch, J A Bluestone
The Journal of Immunology January 15, 1997, 158 (2) 658-665;
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Print ISSN 0022-1767        Online ISSN 1550-6606