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Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.

T Suda, M Tanaka, K Miwa and S Nagata
J Immunol November 1, 1996, 157 (9) 3918-3924;
T Suda
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M Tanaka
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K Miwa
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S Nagata
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Abstract

We have investigated the susceptibility of mouse T cells at various maturation and activation stages to recombinant soluble mouse Fas ligand (termed WX1). CD4+CD8+ thymocytes were preferentially killed by WX1, although CD4+CD8- and CD4-CD8+ thymocytes were also killed at higher concentrations of WX1. The majority of CD4-CD8- thymocytes were resistant to the same doses of WX1. Naive peripheral T cells were also killed by WX1 at concentrations similar to those for single-positive thymocytes. Activation-induced cell death of previously activated T cells is known to be mediated by Fas and Fas ligand. However, the activation of naive splenic T cells by mAbs against CD3/TCR complex rather induced resistance against WX1. This resistance was induced in activated T cells but not in bystander T cells. These mechanisms seem to explain why activated T cells are not immediately killed and why bystander T cells are not activated in an Ag-nonspecific manner.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 157, Issue 9
1 Nov 1996
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Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.
T Suda, M Tanaka, K Miwa, S Nagata
The Journal of Immunology November 1, 1996, 157 (9) 3918-3924;

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Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.
T Suda, M Tanaka, K Miwa, S Nagata
The Journal of Immunology November 1, 1996, 157 (9) 3918-3924;
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Print ISSN 0022-1767        Online ISSN 1550-6606