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Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.

K Kuroda, J Yagi, K Imanishi, X J Yan, X Y Li, W Fujimaki, H Kato, T Miyoshi-Akiyama, Y Kumazawa, H Abe and T Uchiyama
J Immunol August 15, 1996, 157 (4) 1422-1431;
K Kuroda
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J Yagi
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K Imanishi
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X J Yan
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X Y Li
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W Fujimaki
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H Kato
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T Miyoshi-Akiyama
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Y Kumazawa
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H Abe
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T Uchiyama
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Abstract

In the present study we investigated the mechanism of deletion of superantigen (sAg)-reactive T cells expanded in sAg-injected mice. In staphylococcal enterotoxin A (SEA)-injected mice, IL-2 activity in serum peaked at 1 to 3 h and the expression of IL-2R alpha-chain (IL-2R alpha) on SEA-reactive (V beta 3+, or V beta 11+) T cells peaked at 6 to 12 h after the injection. Expansion of V beta 3+ or V beta 11+ T cells peaked at 2 days after the injection when most of these T cells were IL-2R alpha negative, and IL-2 activity was not detected at all in serum, suggesting the involvement of IL-2 deprivation in the deletion of expanded T cells. Implantation of an osmotic pump containing human rIL-2 (IL-2 pump) prolonged the expanded states of V beta 3+ or V beta 11+ T cells in SEA-injected C57BL/6 mice and of V beta 8+ T cells in SEB-injected MRL +/+ and Fas Ag-defective MRL-Ipr/Ipr mice. Adult thymectomy did not change at all the effect induced by implantation of IL-2 pump. DNA fragmentation was blocked substantially in mice co-treated with SEA and IL-2 pump. In addition, CD4+ T cell blasts, obtained by in vitro stimulation with rIL-2 of splenic CD4+ T cells from mice co-treated with SEA and IL-2 pump, produced substantial amounts of IL-2 upon restimulation with SEA. These results indicate that deprivation of IL-2 is deeply involved in the deletion of expanded sAg-reactive T cells and their anergy induction in sAg-injected mice.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 157, Issue 4
15 Aug 1996
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Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.
K Kuroda, J Yagi, K Imanishi, X J Yan, X Y Li, W Fujimaki, H Kato, T Miyoshi-Akiyama, Y Kumazawa, H Abe, T Uchiyama
The Journal of Immunology August 15, 1996, 157 (4) 1422-1431;

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Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.
K Kuroda, J Yagi, K Imanishi, X J Yan, X Y Li, W Fujimaki, H Kato, T Miyoshi-Akiyama, Y Kumazawa, H Abe, T Uchiyama
The Journal of Immunology August 15, 1996, 157 (4) 1422-1431;
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Print ISSN 0022-1767        Online ISSN 1550-6606