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Activated B cells express CD28/B7-independent costimulatory activity.

L Ding and E M Shevach
J Immunol August 15, 1996, 157 (4) 1389-1396;
L Ding
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E M Shevach
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Abstract

Resting and activated B cells display distinct phenotypes and functional properties. Resting B cells are incompetent accessory cells whereas activated B cells are capable of triggering T cell activation. The up-regulation of expression of the B7 family of molecules has been considered to be the primary reason for this functional conversion of activated B cells. We report here that activation of B cells induces a novel costimulatory activity for induction of T cell proliferation, which is independent of the CD28/B7 costimulatory pathway. B cells activated by different stimuli expressed comparable levels of many of the known counter-receptors for costimulation and intercellular adhesion (B7-1, B7-2, HSA, ICAM-1), but differed markedly in their capacity to activate CD4+ T cells from CD28-deficient (-/-) mice. Activation of B cells via CD40, and to a lesser extent with LPS, induced potent B7/CD28-independent costimulatory activity that resulted in marked augmentation of IL-2-mediated proliferative responses of CD4+ T cells from CD28 -/- mice. The B7/CD28-independent costimulatory pathway was capable of triggering the activation of naive CD4+ T cells, as both sorted CD45RBhigh and isolated high density naive CD4+ T cells from CD28 -/- mice responded vigorously to the costimulation provided by CD40L-activated B cells.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 157, Issue 4
15 Aug 1996
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Activated B cells express CD28/B7-independent costimulatory activity.
L Ding, E M Shevach
The Journal of Immunology August 15, 1996, 157 (4) 1389-1396;

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Activated B cells express CD28/B7-independent costimulatory activity.
L Ding, E M Shevach
The Journal of Immunology August 15, 1996, 157 (4) 1389-1396;
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Print ISSN 0022-1767        Online ISSN 1550-6606