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Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus.

M A Berman, C I Sandborg, Z Wang, K L Imfeld, F Zaldivar Jr, V Dadufalza and B A Buckingham
J Immunol November 15, 1996, 157 (10) 4690-4696;
M A Berman
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C I Sandborg
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Z Wang
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K L Imfeld
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F Zaldivar
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V Dadufalza
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B A Buckingham
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Abstract

IL-4 has been shown to protect against diabetes development in rodent models of insulin-dependent (type I) diabetes mellitus (IDDM). To study IL-4 production in human IDDM, PBMC from IDDM patients and controls were stimulated in vitro with PHA, anti-CD3 mAb, or PMA and ionophore. IL-4 production by PBMC or T cells was strongly impaired in IDDM patients at diabetes onset (p < 0.0001). The mean IL-4 response of patients in the honeymoon stage was higher than the mean of the new onset patients, but significantly lower than the control group (p = 0.01). Patients with IDDM of longer duration (>2 yr) showed a wide range of IL-4 responses and their mean IL-4 response was lower than the controls; however, the difference was not statistically significant. IL-4 mRNA levels were measured using competitive reverse transcription PCR. The results showed greatly reduced mRNA levels in new onset IDDM. In contrast, IL-1 production (measured by ELISA) and IFN-gamma mRNA (measured by reverse transcription PCR) were not significantly different in IDDM. The results suggest an imbalance of inflammatory vs anti-inflammatory cytokine production at the onset of IDDM. Deficient IL-4 production as seen at the onset of IDDM may play a role in the development of diabetes by allowing the inflammatory/autoimmune process in pancreatic islets to progress.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 157, Issue 10
15 Nov 1996
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Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus.
M A Berman, C I Sandborg, Z Wang, K L Imfeld, F Zaldivar, V Dadufalza, B A Buckingham
The Journal of Immunology November 15, 1996, 157 (10) 4690-4696;

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Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus.
M A Berman, C I Sandborg, Z Wang, K L Imfeld, F Zaldivar, V Dadufalza, B A Buckingham
The Journal of Immunology November 15, 1996, 157 (10) 4690-4696;
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