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Induction of antitumor immunity using bone marrow-generated dendritic cells.

A Porgador, D Snyder and E Gilboa
J Immunol April 15, 1996, 156 (8) 2918-2926;
A Porgador
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D Snyder
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E Gilboa
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Abstract

We have previously shown that bone marrow-generated dendritic cells (DC) pulsed with a class I-restricted peptide are potent inducers of CD8+ CTL. In the present study we have investigated whether bone marrow-generated DC are capable of inducing antitumor immunity. We show that a single immunization with DC pulsed with OVA peptide was highly effective in eliciting a protective immune response against a challenge with tumor cells expressing the OVA gene (E.G7-OVA), more so than immunization with irradiated E.G7-OVA cells, OVA peptide-pulsed RMA-S cells, or free OVA peptide mixed with adjuvant. The addition of free OVA protein to day 4 or day 7 bone marrow cultures, but not to day 9 mature DC, was also effective in eliciting CTL and engendering antitumor immunity, but was less effective than peptide-pulsed DC. Induction of CTL and antitumor immunity by bone marrow-generated DC pulsed with the class I-restricted OVA peptide correlated with the expression of syngeneic MHC class II molecules on the DC. This and the fact that induction of tumor immunity was dependent on CD4+ T cells suggest that in vivo priming of CTL and induction of antitumor immunity by bone marrow-generated DC also require the presentation of MHC class II-restricted epitopes and activation of CD4+ T cells. This observation has potentially important implications to the use of peptide-pulsed DC in clinical immunotherapy.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 8
15 Apr 1996
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Induction of antitumor immunity using bone marrow-generated dendritic cells.
A Porgador, D Snyder, E Gilboa
The Journal of Immunology April 15, 1996, 156 (8) 2918-2926;

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Induction of antitumor immunity using bone marrow-generated dendritic cells.
A Porgador, D Snyder, E Gilboa
The Journal of Immunology April 15, 1996, 156 (8) 2918-2926;
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Print ISSN 0022-1767        Online ISSN 1550-6606