In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis. Short term cellular and molecular effects.

H M Lorenz, C Antoni, T Valerius, R Repp, M Grünke, N Schwerdtner, H Nüsslein, J Woody, J R Kalden and B Manger
J Immunol February 15, 1996, 156 (4) 1646-1653;

Article Information

vol. 156 no. 4 1646-1653
PubMed 
8568271
Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Published online February 15, 1996.
Copyright & Usage 
Copyright © 1996 by American Association of Immunologists

Author Information

  1. H M Lorenz,
  2. C Antoni,
  3. T Valerius,
  4. R Repp,
  5. M Grünke,
  6. N Schwerdtner,
  7. H Nüsslein,
  8. J Woody,
  9. J R Kalden and
  10. B Manger
  1. Department of Internal Medicine III, University of Erlangen-Nuremberg, Germany.

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Sep 2000100
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Total 2000400
Feb 2001400
Mar 2001100
Apr 2001100
May 2001500
Jun 2001300
Jul 2001400
Aug 20011100
Sep 2001300
Oct 2001300
Nov 2001105
Dec 2001104
Total 20013709
Jan 2002608
Feb 2002100
Mar 2002106
Apr 2002104
May 2002005
Jun 2002006
Jul 20022014
Aug 2002005
Sep 2002100
Oct 2002008
Nov 20023010
Dec 20022017
Total 200217083
Jan 2003007
Feb 20031011
Mar 20031012
Apr 2003102
May 2003108
Jun 200315129
Jul 20033116
Aug 20038012
Sep 20031006
Oct 2003407
Nov 20035010
Dec 2003805
Total 2003572125
Jan 20041205
Feb 20045025
Mar 20047021
Apr 2004505
May 2004509
Jun 2004307
Jul 2004506
Aug 2004804
Sep 2004204
Oct 2004407
Nov 20049016
Dec 2004504
Total 2004700113
Jan 2005503
Feb 2005807
Mar 20057011
Apr 2005202
May 2005203
Jun 2005505
Jul 2005403
Aug 2005308
Sep 2005501
Oct 2005509
Nov 20051319
Dec 2005202
Total 200561163
Jan 2006604
Feb 2006702
Mar 2006509
Apr 2006104
May 2006405
Jun 2006203
Jul 2006302
Aug 2006506
Sep 2006605
Oct 20061008
Nov 20061106
Dec 20061306
Total 200673060
Jan 20071505
Feb 200711015
Mar 2007806
Apr 2007101
May 2007304
Jun 2007103
Jul 2007103
Aug 2007502
Sep 2007601
Oct 2007500
Nov 2007300
Dec 2007603
Total 200765043
Jan 2008702
Feb 2008905
Mar 2008804
Apr 20086017
May 20086021
Jun 2008509
Jul 20081206
Aug 2008504
Sep 2008503
Oct 20081106
Nov 20081608
Dec 2008504
Total 200895089
Jan 200911011
Feb 2009404
Mar 20091306
Apr 2009403
May 2009403
Jun 2009404
Jul 2009502
Aug 2009401
Sep 2009805
Oct 2009107
Nov 2009304
Dec 2009607
Total 200967057
Jan 2010706
Feb 2010501
Mar 2010705
Apr 2010602
May 20101004
Jun 2010403
Jul 2010305
Aug 2010504
Sep 2010904
Oct 2010500
Nov 20101107
Dec 20106011
Total 201078052
Jan 2011402
Feb 201111016
Mar 2011602
Apr 2011904
May 2011304
Jun 2011702
Jul 20111003
Aug 2011503
Sep 2011601
Oct 2011800
Nov 20111002
Dec 20111602
Total 201195041
Jan 20121305
Feb 20121401
Mar 20121103
Apr 20121404
May 20126011
Jun 20122001
Jul 20121705
Aug 20121608
Sep 2012901
Oct 20121807
Nov 20121504
Dec 20121402
Total 2012167052
Jan 20131303
Feb 20131509
Mar 20132108
Apr 20131505
May 201323019
Jun 2013902
Jul 2013705
Aug 20131104
Sep 2013800
Oct 20131602
Nov 2013701
Dec 2013601
Total 2013151059
Jan 2014703
Feb 2014705
Mar 20141405
Apr 2014602
May 20142004
Jun 2014203
Jul 20141501
Aug 2014306
Sep 20141003
Oct 20141003
Nov 2014601
Dec 2014804
Total 2014108040
Jan 2015102
Feb 2015704
Mar 2015500
Apr 2015600
May 2015500
Jun 2015406
Jul 2015507
Aug 20154106
Sep 20152104
Oct 2015702
Nov 2015900
Dec 2015500
Total 2015116031
Jan 2016200
Feb 20162202
Mar 2016400
Apr 2016602
May 2016400
Jun 20161101
Jul 2016302
Aug 2016301
Sep 2016603
Oct 20161103
Nov 2016203
Dec 20161004
Total 201684021
Jan 20174301
Feb 20171402
Mar 20172502
Apr 20171400
May 20173103
Jun 20172701
Jul 2017501
Aug 2017502
Sep 20171602
Oct 20171100
Nov 20172701
Dec 20171402
Total 2017232017
Jan 20181101
Feb 20181203
Mar 20181700
Apr 20181505
May 20181100
Jun 2018702
Jul 2018300
Aug 2018500
Sep 2018900
Oct 2018801
Nov 2018500
Dec 20181002
Total 2018113014
Jan 20191803
Feb 2019302
Mar 20191403
Apr 2019400
May 2019300
Jun 2019300
Jul 20191201
Aug 20191000
Sep 20192001
Oct 20191401
Nov 20192801
Dec 20191000
Total 2019139012
Jan 20202900
Feb 2020900
Mar 20202101
Apr 20202104
May 2020701
Jun 20201402
Jul 20201400
Aug 2020601
Sep 2020800
Oct 2020600
Nov 20202400
Dec 20201500
Total 202017409
Jan 20211102
Feb 20211805
Mar 20212004
Apr 20215302
May 20211600
Total 2021118013
Total212131003

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