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CD30 expression does not discriminate between human Th1- and Th2-type T cells.

D Hamann, C M Hilkens, J L Grogan, S M Lens, M L Kapsenberg, M Yazdanbakhsh and R A van Lier
J Immunol February 15, 1996, 156 (4) 1387-1391;
D Hamann
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C M Hilkens
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J L Grogan
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S M Lens
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M L Kapsenberg
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M Yazdanbakhsh
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R A van Lier
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Abstract

CD30 is a member of the TNF receptor superfamily that is commonly used as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease. More recently, it has been proposed that CD30 is preferentially up-regulated on Th2-type human T cells. We analyzed regulation of CD30 expression on both peripheral blood T cells and T cell clones. In short-term culture, CD30 expression could be induced on T cells by Ags that elicit Th2-type responses (Schistosoma haematobium, adult worm Ag, and Toxocaria canis, excretory/secretory Ag) and Th0-type responses (tetanus toxoid), as well as Th1-type responses (tuberculin purified protein derivative). Moreover, simultaneous measurement of membrane phenotype and cytokine production showed that CD30-expressing cells can produce IFN-gamma. Finally, within panels of randomly generated as well as Ag-specific T cell clones, CD30 expression was found on Th0-, Th2-, and Th1-type clones. We conclude that induction of CD30 on activated T cells is not related to differentiation in Th0-, Th1-, or Th2-type cells.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 4
15 Feb 1996
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CD30 expression does not discriminate between human Th1- and Th2-type T cells.
D Hamann, C M Hilkens, J L Grogan, S M Lens, M L Kapsenberg, M Yazdanbakhsh, R A van Lier
The Journal of Immunology February 15, 1996, 156 (4) 1387-1391;

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CD30 expression does not discriminate between human Th1- and Th2-type T cells.
D Hamann, C M Hilkens, J L Grogan, S M Lens, M L Kapsenberg, M Yazdanbakhsh, R A van Lier
The Journal of Immunology February 15, 1996, 156 (4) 1387-1391;
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Print ISSN 0022-1767        Online ISSN 1550-6606