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flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors.

B E Hunte, S Hudak, D Campbell, Y Xu and D Rennick
J Immunol January 15, 1996, 156 (2) 489-496;
B E Hunte
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S Hudak
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D Campbell
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Y Xu
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D Rennick
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Abstract

We have investigated the role of flk2/flt3 ligand (FL) in B cell lymphopoiesis. The ability of FL to stimulate the growth of immature B cells was assessed using distinct populations: CD43lowB220+ pre-B cells, CD43+B220+ pro-B cells, and CD43+B220low progenitors. FL failed to affect the growth of the pro-B or pre-B cells whether used alone or in combination with stem cell factor (SCF) or IL-7. In striking contrast, FL was a potent cofactor for the CD43+B220low progenitor cells, interacting with either IL-7 and/or SCF to stimulate their growth. The combination of FL with IL-7 plus SCF stimulated maximum expansion of these cells, albeit, less than that stimulated in stromal cell cultures. When the CD43+B220low progenitors were divided based on expression of heat stable Ag (CD24) into a CD24- and a CD24+ subset, the FL-responsive cells were contained only within the CD24- subset. FL interacted with SCF or with IL-7 to stimulate their growth resulting in a 20- and 50-fold increase in cellularity, respectively. Since the CD24- subset was the most immature of the B cell populations studied, our data suggest that FL costimulates the expansion of very primitive B cell progenitors.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 2
15 Jan 1996
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flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors.
B E Hunte, S Hudak, D Campbell, Y Xu, D Rennick
The Journal of Immunology January 15, 1996, 156 (2) 489-496;

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flk2/flt3 ligand is a potent cofactor for the growth of primitive B cell progenitors.
B E Hunte, S Hudak, D Campbell, Y Xu, D Rennick
The Journal of Immunology January 15, 1996, 156 (2) 489-496;
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