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Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

L Olcese, P Lang, F Vély, A Cambiaggi, D Marguet, M Bléry, K L Hippen, R Biassoni, A Moretta, L Moretta, J C Cambier and E Vivier
J Immunol June 15, 1996, 156 (12) 4531-4534;
L Olcese
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P Lang
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F Vély
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A Cambiaggi
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D Marguet
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M Bléry
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K L Hippen
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R Biassoni
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A Moretta
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L Moretta
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J C Cambier
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E Vivier
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Abstract

NK cells express cell surface receptors for MHC class I proteins (KIR). Engagement of these receptors inhibits NK cell cytotoxic programs. KIR can be expressed on T cells, and their engagement also results in inhibition of effector functions initiated by the CD3/TCR complex. While human KIR genes belong to the Ig gene superfamily, mouse KIR belong to a family of dimeric lectins. Despite these distinct evolutionary origins, we show here that both HLA-Cw3-specific human p58.183 receptors and H-2D d/k-specific mouse Ly49A receptors recruit the same protein tyrosine phosphatases, PTP1C and PTP1D, upon phosphorylation of critical intracytoplasmic tyrosine residues. These results document a common pathway by which diverse KIR can down-regulate NK and T cell activation programs, and further define the sequence of the immunoreceptor tyrosine-based inhibitory motif (ITIM), initially described in FcgammaRIIB1, and expressed in both human and mouse KIR.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 12
15 Jun 1996
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Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.
L Olcese, P Lang, F Vély, A Cambiaggi, D Marguet, M Bléry, K L Hippen, R Biassoni, A Moretta, L Moretta, J C Cambier, E Vivier
The Journal of Immunology June 15, 1996, 156 (12) 4531-4534;

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Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.
L Olcese, P Lang, F Vély, A Cambiaggi, D Marguet, M Bléry, K L Hippen, R Biassoni, A Moretta, L Moretta, J C Cambier, E Vivier
The Journal of Immunology June 15, 1996, 156 (12) 4531-4534;
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Print ISSN 0022-1767        Online ISSN 1550-6606