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Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein.

S Tamura, K Miyata, K Matsuo, H Asanuma, H Takahashi, K Nakajima, Y Suzuki, C Aizawa and T Kurata
J Immunol May 15, 1996, 156 (10) 3892-3900;
S Tamura
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K Miyata
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K Matsuo
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H Asanuma
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H Takahashi
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K Nakajima
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Y Suzuki
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C Aizawa
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T Kurata
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Abstract

The protective roles of influenza viral nucleoprotein (NP), together with the cellular mechanism of the protection in the nasal site, were examined in BALB/c mice immunized intranasally with an adjuvant (cholera toxin B subunit containing 0.2% of the whole toxin)-combined A or B virus recombinant NP. The NP-immune mice, when challenged intranasally with a sublethal dose of the virus 3 wk after immunization, had accelerated virus clearance from the nasal site in both an influenza type-specific and a nonspecific manner, as shown by the protection from high morbidity from the second day after challenge. Both type-specific and nonspecific acceleration of recovery was confirmed by the increased survival rate after challenge with a lethal dose of virus in mice immunized and boosted with adjuvant-combined NP. The acceleration of nasal virus clearance was accompanied with acceleration of type-specific systemic delayed-type hypersensitivity (DTH) and with IFN-gamma production by nasal lymphocytes. The nasal lymphocytes from the immunized and challenged mice generated a significantly high level of DTH when transferred locally, but no class I MHC-restricted CTL response. Moreover, nasal CD4+ T cells, induced by NP immunization and increased in number by the subsequent challenge, were involved in the accelerated IFN-gamma production. These results suggest that nasal Th1 cells, capable of producing IFN-gamma and mediating DTH, are involved in the type-specific acceleration of recovery from influenza after challenge in mice immunized intranasally with adjuvant-combined NP, although the nonspecific mechanism of accelerated recovery remains to be solved.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 10
15 May 1996
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Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein.
S Tamura, K Miyata, K Matsuo, H Asanuma, H Takahashi, K Nakajima, Y Suzuki, C Aizawa, T Kurata
The Journal of Immunology May 15, 1996, 156 (10) 3892-3900;

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Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein.
S Tamura, K Miyata, K Matsuo, H Asanuma, H Takahashi, K Nakajima, Y Suzuki, C Aizawa, T Kurata
The Journal of Immunology May 15, 1996, 156 (10) 3892-3900;
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Print ISSN 0022-1767        Online ISSN 1550-6606