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Regulation of the Fas lytic pathway in cloned CTL.

A Glass, C M Walsh, D H Lynch and W R Clark
J Immunol May 15, 1996, 156 (10) 3638-3644;
A Glass
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C M Walsh
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D H Lynch
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W R Clark
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Abstract

Cloned murine CTL activated via the TCR or by PMA and ionomycin up-regulate surface Fas ligand and show an increased ability to kill non-Ag-specific Fas+ target cells. This up-regulation starts after 45 to 60 min and has a t1/2 for reversal of about 90 min. Up-regulation of lytic function is accompanied by up-regulation of Fas ligand on the CTL surface, which can be blocked by protein synthesis inhibitors. When up-regulation of Fas lytic function was induced by PMA and ionomycin, EGTA blocked both activation of lytic function and expression of Fas ligand detected by FACS analysis. However, when up-regulation was induced by specific Ag, EGTA blocked activation of lytic function, but not up-regulation of Fas ligand. Moreover, EL-4 cells have very high levels of surface Fas ligand, although they are not cytotoxic. Thus, expression of surface Fas ligand may be required, but not sufficient, for Fas-mediated lysis.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 10
15 May 1996
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Regulation of the Fas lytic pathway in cloned CTL.
A Glass, C M Walsh, D H Lynch, W R Clark
The Journal of Immunology May 15, 1996, 156 (10) 3638-3644;

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Regulation of the Fas lytic pathway in cloned CTL.
A Glass, C M Walsh, D H Lynch, W R Clark
The Journal of Immunology May 15, 1996, 156 (10) 3638-3644;
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Print ISSN 0022-1767        Online ISSN 1550-6606