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Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

I A Ferber, S Brocke, C Taylor-Edwards, W Ridgway, C Dinisco, L Steinman, D Dalton and C G Fathman
J Immunol January 1, 1996, 156 (1) 5-7;
I A Ferber
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S Brocke
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C Taylor-Edwards
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W Ridgway
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C Dinisco
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L Steinman
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D Dalton
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C G Fathman
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Abstract

Experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, is an autoimmune disorder seen in mice and rats following immunization with myelin basic protein (MBP) or MBP-derived peptides. IFN-gamma, a cytokine produced by a variety of cells, is involved in many inflammatory and immune regulatory events. Contradictory results concerning exacerbations and the disease course were seen comparing injections of IFN-gamma in humans suffering from multiple sclerosis to studies using anti-IFN-gamma Abs in mice with EAE. To study the role of IFN-gamma and IFN-gamma-producing cells in EAE, we crossed IFN-gamma knockout mice (H-2b) (unable to produce IFN-gamma due to the disruption of the IFN-gamma gene) with an EAE-susceptible mouse strain, B10.PL (H-2u). EAE was seen in IFN-gamma knockout mice, heterozygotic (IFN-gamma +/-) mice, as well as wild-type littermates following immunization with MBP. Histologic analyses of the central nervous system of IFN-gamma knockout mice with EAE revealed massive infiltrates composed of lymphocytes, macrophages, and granulocytes. We conclude that the presence of IFN-gamma is not crucial to the induction or the clinical course of EAE.

  • Copyright © 1996 by American Association of Immunologists

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The Journal of Immunology
Vol. 156, Issue 1
1 Jan 1996
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Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
I A Ferber, S Brocke, C Taylor-Edwards, W Ridgway, C Dinisco, L Steinman, D Dalton, C G Fathman
The Journal of Immunology January 1, 1996, 156 (1) 5-7;

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Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
I A Ferber, S Brocke, C Taylor-Edwards, W Ridgway, C Dinisco, L Steinman, D Dalton, C G Fathman
The Journal of Immunology January 1, 1996, 156 (1) 5-7;
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Print ISSN 0022-1767        Online ISSN 1550-6606