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Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK.

H S Kim, X Zhang, E Klyushnenkova and Y S Choi
J Immunol August 1, 1995, 155 (3) 1101-1109;
H S Kim
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X Zhang
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E Klyushnenkova
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Y S Choi
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Abstract

To identify the signals given to the germinal center (GC) B cells by FDC, we have established an FDC-like cell line, HK. HK cells have the important functions of FDC, which are the preferential binding and stimulation of GC B cells. Cell-cell interaction between IgD- B cells and HK cells resulted in the rescue of these cells from apoptosis, whereas the majority of unbound B cells or B cells cultured in the absence of HK cells underwent apoptosis. We investigated the effects of HK cells on the subpopulations of tonsillar B lymphocytes that are at different stages of maturation and differentiation. The subpopulations of tonsillar B cells were purified by panning and/or MACS according to the surface expression of IgD, CD38, and CD44. Although HK cells alone did not stimulate B cell proliferation, HK cells in the presence of either anti-mu or anti-CD40 significantly enhanced the proliferation of B cells. The data show that HK cells preferentially bind, rescue, and stimulate GC B cells (IgD-CD38+) generating CD38-CD44+ memory B cells. The costimulation activity of HK cells is also provided in a form of soluble factor(s). Hence, the phenotypic and functional analysis of HK cells suggests that these cells may be derived from FDC.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 155, Issue 3
1 Aug 1995
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Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK.
H S Kim, X Zhang, E Klyushnenkova, Y S Choi
The Journal of Immunology August 1, 1995, 155 (3) 1101-1109;

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Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK.
H S Kim, X Zhang, E Klyushnenkova, Y S Choi
The Journal of Immunology August 1, 1995, 155 (3) 1101-1109;
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Print ISSN 0022-1767        Online ISSN 1550-6606