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Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

L L Carter and R W Dutton
J Immunol August 1, 1995, 155 (3) 1028-1031;
L L Carter
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R W Dutton
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Abstract

IFN-gamma-secreting T1 and IL-5-secreting T2 subsets of CD8 effectors were generated in vitro using freshly isolated cells from wild-type and perforin knockout mice stimulated with allogeneic Ag-presenting cells. Both T1 and T2 effectors from wild-type mice exhibited perforin-mediated cytolysis. T1, but not T2, populations from perforin knockout mice displayed significant lysis by the Fas-mediated pathway. Th1 cells have recently been shown to be regulated by Fas and we speculate that Fas-mediated mechanisms are involved in the regulation of both Th1 and T1 populations of T cells.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 155, Issue 3
1 Aug 1995
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Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.
L L Carter, R W Dutton
The Journal of Immunology August 1, 1995, 155 (3) 1028-1031;

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Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.
L L Carter, R W Dutton
The Journal of Immunology August 1, 1995, 155 (3) 1028-1031;
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Print ISSN 0022-1767        Online ISSN 1550-6606