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Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis.

Y X Zhao and A Tarkowski
J Immunol December 15, 1995, 155 (12) 5736-5742;
Y X Zhao
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A Tarkowski
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Abstract

The role of IFN-gamma in the regulation of host resistance of Staphylococcus aureus was studied using IFN-gamma receptor-deficient (IFN-gamma R-/-) mice in a model of S. aureus-induced septicemia and arthritis. IFN-gamma R-/- mice and wild-type controls were inoculated intravenously with a toxic shock syndrome toxin-1-producing S. aureus LS-1 strain. IFN-gamma R-/- mice displayed significantly more frequent and more severe arthritis compared with wild-type littermates (p < 0.01) throughout the course of infection. Notably, IFN-gamma R-/- mice developed severe sepsis with high mortality early after the inoculation with staphylococci. However, the mortality of wild-type mice became significantly higher at later stages of the disease compared with IFN-gamma R-/- mice (p < 0.05). This differential outcome of sepsis-related mortality was associated with deficiencies of bacterial elimination from blood and parenchymatous organs and correlated well to serum levels of IL-6 and spleen IL-1 beta and TNF-beta mRNA expression. Thus, bacterial growth and proinflammatory cytokines IL-1 beta, TNF-beta, and IL-6 were higher at the early stage of infection in IFN-gamma-/- mice but increased at the later stage in wild-type littermates. Our data indicate that the absence of IFN-gamma R leads to harmful as well as beneficial effects in S. aureus infection, depending on the stage of the disease and the localization of the infection.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 155, Issue 12
15 Dec 1995
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Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis.
Y X Zhao, A Tarkowski
The Journal of Immunology December 15, 1995, 155 (12) 5736-5742;

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Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis.
Y X Zhao, A Tarkowski
The Journal of Immunology December 15, 1995, 155 (12) 5736-5742;
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Print ISSN 0022-1767        Online ISSN 1550-6606