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Surrogate light chain-dependent selection of Ig heavy chain V regions.

U Keyna, G B Beck-Engeser, J Jongstra, S E Applequist and H M Jäck
J Immunol December 15, 1995, 155 (12) 5536-5542;
U Keyna
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G B Beck-Engeser
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J Jongstra
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S E Applequist
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H M Jäck
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Abstract

Bone marrow B cell precursors frequently rearrange the Ig heavy chain variable (VH) gene segment VH81X. It is puzzling, therefore, that mature B cells in adult mice rarely express mu-heavy chains bearing this VH gene segment. We show in this work in transformed pre-B cell lines that two VH81X/mu-chains that differ in their VH-D-JH joining sequences are not assembled covalently with the B cell precursor-specific surrogate light (SL) chain and are not expressed on the cell surface. From these findings, we propose that a B cell precursor clonally expands and proceeds to the next developmental stage only if it expresses a mu-chain with a VH domain that, together with the SL chain, directs the formation of a signal-transducing mu/SL chain membrane complex. Therefore, a checkpoint exists early in B cell development, at which SL chain not only screens B cell precursors for the presence of a full-length mu-chain, but also for a VH domain that promotes the assembly of a mu/SL chain complex.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 155, Issue 12
15 Dec 1995
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Surrogate light chain-dependent selection of Ig heavy chain V regions.
U Keyna, G B Beck-Engeser, J Jongstra, S E Applequist, H M Jäck
The Journal of Immunology December 15, 1995, 155 (12) 5536-5542;

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Surrogate light chain-dependent selection of Ig heavy chain V regions.
U Keyna, G B Beck-Engeser, J Jongstra, S E Applequist, H M Jäck
The Journal of Immunology December 15, 1995, 155 (12) 5536-5542;
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Print ISSN 0022-1767        Online ISSN 1550-6606