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Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.

T Suzuki, K Hiromatsu, Y Ando, T Okamoto, Y Tomoda and Y Yoshikai
J Immunol May 1, 1995, 154 (9) 4476-4484;
T Suzuki
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K Hiromatsu
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Y Ando
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T Okamoto
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Y Tomoda
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Y Yoshikai
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Abstract

To elucidate the potential roles of the gamma delta T cells in uterine intraepithelial lymphocytes (IEL) in the regulation of maternal antifetal immune response during pregnancy, we examined the kinetics and function of gamma delta T cells in uterine IEL obtained from (C3H/He x AKR/J) pregnancy. The number of gamma delta T cells increased in the uterine IEL in (C3H/HexAKR/J) pregnancy more than those in (C3H/HexC3H/He) pregnancy and much more than in nonpregnant C3H/He mice. The uterine IEL in (C3H/HexC3H/He) pregnancy significantly proliferated in response to AKR/J stimulator cells. In contrast, the uterine IEL in (C3H/HexAKR/J) pregnancy showed little, if any, proliferation in response to the same stimulator cells. gamma delta T cell depletion from the uterine IEL in (C3H/HexAKR/J) pregnancy restored their responsiveness against AKR/J stimulator cells. Both gamma delta T cell-enriched fraction and alpha beta T cell-depleted fraction, but neither gamma delta T cell-depleted fraction nor alpha beta T cell-enriched fraction in the uterine IEL exhibited suppressive activity against allogeneic responses of nonpregnant C3H/He LN cells. This suppressive activity was shown by transferring the supernatant of culture medium in the uterine IEL stimulated with AKR/J cells that contained a large amount of TGF-beta, and the suppressive activity was significantly blocked by addition of anti-TGF-beta mAb to the culture. Taken together, our results suggest that gamma delta T cells in the uterine IEL suppress the maternal antifetal immune response at the maternal-fetal interface at least in part through TGF-beta production to prevent a rejection of the fetus.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 154, Issue 9
1 May 1995
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Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.
T Suzuki, K Hiromatsu, Y Ando, T Okamoto, Y Tomoda, Y Yoshikai
The Journal of Immunology May 1, 1995, 154 (9) 4476-4484;

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Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response.
T Suzuki, K Hiromatsu, Y Ando, T Okamoto, Y Tomoda, Y Yoshikai
The Journal of Immunology May 1, 1995, 154 (9) 4476-4484;
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Print ISSN 0022-1767        Online ISSN 1550-6606