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T cell gelatinases mediate basement membrane transmigration in vitro.

D Leppert, E Waubant, R Galardy, N W Bunnett and S L Hauser
J Immunol May 1, 1995, 154 (9) 4379-4389;
D Leppert
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E Waubant
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R Galardy
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N W Bunnett
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S L Hauser
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Abstract

T cell homing into extravascular sites requires penetration across the subendothelial basal lamina, a specialized nonfibrillar connective tissue structure that anchors endothelial cells to parenchymal surfaces. Herein, we show that normal human T cells express gelatinases A and B, two matrix metalloproteinases active against the major basal lamina constituents, collagen types IV and V. Expression is confirmed at both the mRNA and protein levels. Gelatinase B is expressed constitutively, whereas gelatinases A and B expression is induced by T cell activation. In vitro migration of resting T cells across a basal lamina equivalent is mediated by gelatinase B, because it is specifically blocked by GM6001, a hydroxamic acid inhibitor of matrix metalloproteinases. Inhibition of T cell homing by interference with gelatinase function may represent a useful approach to the treatment of T cell-mediated autoimmune diseases.

  • Copyright © 1995 by American Association of Immunologists
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The Journal of Immunology
Vol. 154, Issue 9
1 May 1995
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T cell gelatinases mediate basement membrane transmigration in vitro.
D Leppert, E Waubant, R Galardy, N W Bunnett, S L Hauser
The Journal of Immunology May 1, 1995, 154 (9) 4379-4389;

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T cell gelatinases mediate basement membrane transmigration in vitro.
D Leppert, E Waubant, R Galardy, N W Bunnett, S L Hauser
The Journal of Immunology May 1, 1995, 154 (9) 4379-4389;
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Print ISSN 0022-1767        Online ISSN 1550-6606