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Do HLA genes play a prominent role in determining T cell receptor V alpha segment usage in humans?

B Gulwani-Akolkar, B Shi, P N Akolkar, K Ito, W B Bias and J Silver
J Immunol April 15, 1995, 154 (8) 3843-3851;
B Gulwani-Akolkar
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B Shi
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P N Akolkar
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K Ito
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W B Bias
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J Silver
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Abstract

Previous studies in humans have demonstrated that HLA genes can profoundly influence the TCR V beta repertoire. To similarly assess the influence of HLA genes on the TCR V alpha segment repertoire, the V alpha repertoires of 12 individuals from three unrelated families were determined by quantitative PCR. Each family contained at least one pair of HLA-identical and -nonidentical siblings. Repertoire analysis was performed on purified CD4+ and CD8+ cells by using V alpha-specific primers. We were unable to demonstrate more similar V alpha repertoires between HLA-identical siblings than between HLA-nonidentical siblings. In contrast, when a similar analysis was performed on the same individuals for the V beta repertoire, HLA-identical siblings were found to have significantly more similar repertoires than HLA-nonidentical siblings. Furthermore, both the V alpha and V beta repertoires of monozygotic twins showed striking similarity. Despite our inability to show an influence of HLA genes on the V alpha repertoire, we did observe a very strong skewing in terms of preferential expression on CD4+ or CD8+ cells of several V alpha segments, notably TCRAV1, -2, -5, -6, -7, -11, -12, and -13. These studies suggest that HLA genes play less of a role in determining V alpha segment usage than V beta. Nevertheless, the pronounced skewing of V alpha segment expression in the CD4+ or CD8+ populations suggests some role for HLA genes in determining the V alpha TCR repertoire. Furthermore, the striking similarity of V alpha repertoires of identical twins suggests a major role for non-HLA genes in determining the V alpha repertoire.

  • Copyright © 1995 by American Association of Immunologists

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The Journal of Immunology
Vol. 154, Issue 8
15 Apr 1995
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Do HLA genes play a prominent role in determining T cell receptor V alpha segment usage in humans?
B Gulwani-Akolkar, B Shi, P N Akolkar, K Ito, W B Bias, J Silver
The Journal of Immunology April 15, 1995, 154 (8) 3843-3851;

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Do HLA genes play a prominent role in determining T cell receptor V alpha segment usage in humans?
B Gulwani-Akolkar, B Shi, P N Akolkar, K Ito, W B Bias, J Silver
The Journal of Immunology April 15, 1995, 154 (8) 3843-3851;
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