The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

A Sette; A Vitiello; B Reherman; P Fowler; R Nayersina; W M Kast; C J Melief; C Oseroff; L Yuan; J Ruppert; J Sidney; M F del Guercio; S Southwood; R T Kubo; R W Chesnut; H M Grey; F V Chisari

Article Information

vol. 153 no. 12 5586-5592

PubMed

7527444

Published By

The American Association of Immunologists, Inc.

Print ISSN

0022-1767

Online ISSN

1550-6606

History

Published online December 15, 1994.

Author Information

A Sette,
A Vitiello,
B Reherman,
P Fowler,
R Nayersina,
W M Kast,
C J Melief,
C Oseroff,
L Yuan,
J Ruppert,
J Sidney,
M F del Guercio,
S Southwood,
R T Kubo,
R W Chesnut,
H M Grey and
F V Chisari

Cytel, San Diego, CA 92121, USA.

Article usage

Article usage: October 2000 to August 2020

	Abstract	Full	Pdf
Oct 2000	1	0	0
Nov 2000	5	0	0
Dec 2000	3	0	0
Total 2000	9	0	0
Jan 2001	7	0	0
Feb 2001	1	0	0
Mar 2001	23	0	0
Apr 2001	3	0	0
May 2001	9	0	0
Jun 2001	2	0	0
Jul 2001	6	0	0
Aug 2001	6	0	0
Sep 2001	2	0	3
Oct 2001	1	0	5
Nov 2001	6	0	6
Dec 2001	1	0	1
Total 2001	67	0	15
Jan 2002	3	0	4
Feb 2002	2	0	4
Apr 2002	3	0	10
May 2002	1	0	12
Jun 2002	2	0	9
Jul 2002	2	0	10
Aug 2002	0	0	8
Sep 2002	1	0	6
Oct 2002	0	0	15
Nov 2002	4	0	20
Dec 2002	5	0	9
Total 2002	23	0	107
Jan 2003	6	0	9
Feb 2003	5	0	23
Mar 2003	5	0	3
Apr 2003	6	0	23
May 2003	5	0	13
Jun 2003	2	0	10
Jul 2003	2	0	6
Aug 2003	4	0	7
Sep 2003	9	1	7
Oct 2003	8	0	17
Nov 2003	9	0	13
Dec 2003	7	0	3
Total 2003	68	1	134
Jan 2004	17	0	13
Feb 2004	7	0	11
Mar 2004	6	0	8
Apr 2004	15	0	11
May 2004	11	0	8
Jun 2004	10	0	13
Jul 2004	22	0	18
Aug 2004	10	1	13
Sep 2004	18	0	26
Oct 2004	10	0	12
Nov 2004	14	0	14
Dec 2004	10	0	11
Total 2004	150	1	158
Jan 2005	23	0	12
Feb 2005	14	0	11
Mar 2005	18	0	17
Apr 2005	9	0	17
May 2005	1	0	19
Jun 2005	3	0	11
Jul 2005	3	0	11
Aug 2005	11	0	13
Sep 2005	7	0	18
Oct 2005	9	0	12
Nov 2005	12	0	11
Dec 2005	5	0	15
Total 2005	115	0	167
Jan 2006	19	0	16
Feb 2006	2	0	5
Mar 2006	6	0	14
Apr 2006	10	0	19
May 2006	11	0	14
Jun 2006	6	0	10
Jul 2006	18	0	11
Aug 2006	7	0	13
Sep 2006	5	0	9
Oct 2006	22	0	13
Nov 2006	12	0	8
Dec 2006	6	0	9
Total 2006	124	0	141
Jan 2007	6	0	10
Feb 2007	9	0	13
Mar 2007	14	0	19
Apr 2007	2	0	8
May 2007	13	0	14
Jun 2007	8	0	13
Jul 2007	6	0	11
Aug 2007	13	0	10
Sep 2007	11	0	4
Oct 2007	11	0	23
Nov 2007	10	0	7
Dec 2007	10	0	9
Total 2007	113	0	141
Jan 2008	3	0	12
Feb 2008	6	0	8
Mar 2008	14	0	15
Apr 2008	6	0	23
May 2008	18	0	17
Jun 2008	10	0	21
Jul 2008	11	0	13
Aug 2008	12	0	17
Sep 2008	12	0	5
Oct 2008	16	0	11
Nov 2008	16	0	21
Dec 2008	17	0	14
Total 2008	141	0	177
Jan 2009	43	0	7
Feb 2009	11	0	18
Mar 2009	14	0	8
Apr 2009	22	0	17
May 2009	14	0	9
Jun 2009	9	0	8
Jul 2009	16	0	14
Aug 2009	16	0	4
Sep 2009	13	0	12
Oct 2009	17	0	8
Nov 2009	17	0	8
Dec 2009	12	0	6
Total 2009	204	0	119
Jan 2010	16	0	12
Feb 2010	9	0	9
Mar 2010	21	0	13
Apr 2010	27	0	9
May 2010	30	0	11
Jun 2010	17	0	10
Jul 2010	17	0	1
Aug 2010	12	0	5
Sep 2010	14	0	4
Oct 2010	19	0	7
Nov 2010	24	0	9
Dec 2010	22	0	20
Total 2010	228	0	110
Jan 2011	25	0	19
Feb 2011	23	0	21
Mar 2011	31	0	17
Apr 2011	24	0	19
May 2011	21	0	8
Jun 2011	25	0	12
Jul 2011	21	0	9
Aug 2011	33	0	15
Sep 2011	30	0	4
Oct 2011	52	0	13
Nov 2011	44	0	10
Dec 2011	33	0	8
Total 2011	362	0	155
Jan 2012	43	0	5
Feb 2012	44	0	12
Mar 2012	37	0	12
Apr 2012	50	0	14
May 2012	47	0	14
Jun 2012	37	0	12
Jul 2012	25	0	3
Aug 2012	29	0	2
Sep 2012	34	0	6
Oct 2012	41	0	12
Nov 2012	24	0	2
Dec 2012	42	0	5
Total 2012	453	0	99
Jan 2013	64	0	4
Feb 2013	25	0	1
Mar 2013	48	0	10
Apr 2013	54	0	13
May 2013	63	0	20
Jun 2013	41	0	12
Jul 2013	56	0	9
Aug 2013	47	0	9
Sep 2013	60	0	8
Oct 2013	47	0	7
Nov 2013	52	0	9
Dec 2013	50	0	7
Total 2013	607	0	109
Jan 2014	34	0	8
Feb 2014	35	0	5
Mar 2014	64	0	15
Apr 2014	66	0	7
May 2014	57	0	17
Jun 2014	96	0	9
Jul 2014	51	0	13
Aug 2014	24	0	12
Sep 2014	18	0	16
Oct 2014	25	0	7
Nov 2014	50	1	12
Dec 2014	23	0	11
Total 2014	543	1	132
Jan 2015	79	0	13
Feb 2015	29	0	18
Mar 2015	23	0	16
Apr 2015	104	0	12
May 2015	35	0	7
Jun 2015	13	0	14
Jul 2015	27	0	13
Aug 2015	28	0	15
Sep 2015	36	0	8
Oct 2015	106	0	22
Nov 2015	96	0	25
Dec 2015	21	0	4
Total 2015	597	0	167
Jan 2016	150	0	18
Feb 2016	50	0	11
Mar 2016	21	0	13
Apr 2016	47	0	24
May 2016	25	0	9
Jun 2016	55	0	17
Jul 2016	40	0	15
Aug 2016	40	0	11
Sep 2016	33	0	5
Oct 2016	41	0	14
Nov 2016	65	0	19
Dec 2016	28	0	5
Total 2016	595	0	161
Jan 2017	48	0	17
Feb 2017	96	0	6
Mar 2017	59	0	15
Apr 2017	73	0	11
May 2017	51	0	10
Jun 2017	43	0	15
Jul 2017	114	0	18
Aug 2017	66	0	10
Sep 2017	88	0	21
Oct 2017	83	0	16
Nov 2017	45	0	13
Dec 2017	80	0	14
Total 2017	846	0	166
Jan 2018	84	0	11
Feb 2018	98	0	22
Mar 2018	108	0	10
Apr 2018	53	0	12
May 2018	72	0	18
Jun 2018	75	0	9
Jul 2018	82	0	18
Aug 2018	125	0	20
Sep 2018	72	0	18
Oct 2018	69	0	10
Nov 2018	78	0	18
Dec 2018	80	0	12
Total 2018	996	0	178
Jan 2019	43	0	14
Feb 2019	52	0	11
Mar 2019	99	0	21
Apr 2019	80	0	11
May 2019	77	0	10
Jun 2019	35	0	17
Jul 2019	50	0	15
Aug 2019	71	0	10
Sep 2019	63	0	14
Oct 2019	85	0	10
Nov 2019	82	0	13
Dec 2019	36	0	7
Total 2019	773	0	153
Jan 2020	139	0	10
Feb 2020	64	0	15
Mar 2020	124	0	17
Apr 2020	69	0	18
May 2020	107	0	7
Jun 2020	99	0	8
Jul 2020	71	0	5
Aug 2020	64	0	11
Total 2020	737	0	91
Total	7751	3	2680

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The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

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