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Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.

S Husby, J Mestecky, Z Moldoveanu, S Holland and C O Elson
J Immunol May 1, 1994, 152 (9) 4663-4670;
S Husby
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J Mestecky
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Z Moldoveanu
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S Holland
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C O Elson
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Abstract

The purpose of this study was to investigate whether oral tolerance, defined as Ag-specific immunologic unresponsiveness after Ag feeding, could be induced in humans after prolonged Ag ingestion. Eight adult volunteers ingested a total dose of 0.5 g of keyhole limpet hemocyanin (KLH) followed by subcutaneous immunization with KLH. Eight controls received only the subcutaneous immunization. In the group fed KLH, there was a significant reduction in KLH-specific T cell proliferation (p = 0.04) and delayed skin test responses (p = 0.07) to KLH. KLH ingestion alone did not induce significant levels of Abs in either serum or secretions. However, after the subsequent subcutaneous immunization, the number of circulating IgG and IgM anti-KLH-producing cells, the titers of serum IgG, IgA, and IgM anti-KLH Abs, and the titers of IgA anti-KLH Abs in saliva and intestinal secretions were significantly greater in the KLH-fed group than in the nonfed group. We conclude that KLH feeding induced systemic T cell tolerance, but B cell priming, at both systemic and mucosal sites. These studies support the concept of using Ag feeding as a treatment for certain immune-mediated diseases.

  • Copyright © 1994 by American Association of Immunologists

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The Journal of Immunology
Vol. 152, Issue 9
1 May 1994
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Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.
S Husby, J Mestecky, Z Moldoveanu, S Holland, C O Elson
The Journal of Immunology May 1, 1994, 152 (9) 4663-4670;

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Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding.
S Husby, J Mestecky, Z Moldoveanu, S Holland, C O Elson
The Journal of Immunology May 1, 1994, 152 (9) 4663-4670;
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Print ISSN 0022-1767        Online ISSN 1550-6606