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Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb.

S C Morris, A Lees, J M Holmes, R D Jeffries and F D Finkelman
J Immunol April 15, 1994, 152 (8) 3768-3776;
S C Morris
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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A Lees
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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J M Holmes
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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R D Jeffries
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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F D Finkelman
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
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Abstract

T cell tolerance can be induced by B cell presentation of Ags to naive T cells. To further characterize this mechanism of T cell tolerance induction, we have investigated the effects of injecting mice with an intact rat IgG2a Ab, which binds to the B cell low-affinity Fc epsilon receptor (CD23), on the responsiveness of B cells and T cells to rat IgG2a. Our observations indicate that 1) intravenous, subcutaneous, or intraperitoneal injection of this Ab induces antigen-specific B cell and T cell tolerance; 2) both forms of tolerance are induced more completely by injection of rat IgG2a anti-CD23 mAb than by injection of an equal dose of a control rat IgG2a Ig; and 3) reduced responsiveness to Ag is seen as early as 1 to 3 days after anti-CD23 mAb injection and reaches maximum levels by 7 days after injection. Although tolerance induced by the injection of soluble proteins has been reported to be characterized by reduced production of IL-2 and IFN-gamma, but normal production of IL-4, injection of mice with rat IgG2a anti-mouse CD23 mAb greatly decreases the IL-4 response to a rat IgG2a immunogen that normally induces a large IL-4 response.

  • Copyright © 1994 by American Association of Immunologists

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The Journal of Immunology
Vol. 152, Issue 8
15 Apr 1994
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Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb.
S C Morris, A Lees, J M Holmes, R D Jeffries, F D Finkelman
The Journal of Immunology April 15, 1994, 152 (8) 3768-3776;

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Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb.
S C Morris, A Lees, J M Holmes, R D Jeffries, F D Finkelman
The Journal of Immunology April 15, 1994, 152 (8) 3768-3776;
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