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Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade.

K D Chavin, L Qin, R Yon, J Lin, H Yagita and J S Bromberg
J Immunol April 15, 1994, 152 (8) 3729-3739;
K D Chavin
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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L Qin
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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R Yon
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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J Lin
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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H Yagita
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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J S Bromberg
Department of Surgery, Medical University of South Carolina, Charleston 29425.
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Abstract

The mechanism by which anti-CD2 mAbs inhibit hapten-specific and alloantigen specific CTL was explored. In vivo administration of alpha-CD2 mAbs resulted in 80 to 100% inhibition of alloantigen specific CTLs. Mixing cells from control animals with cells from alpha-CD2-treated groups demonstrated transferable suppression of CTL (40-67% suppression). These suppressor cells were CD4+CD8- and associated with increased IL-4 and TGF-beta in culture as compared with controls. Anti-CD2 mAbs added at the initiation of culture resulted in 60 to 72% inhibition of trinitrophenyl-CTL, whereas mAbs added at the time of assay resulted in less than 50% inhibition of trinitrophenyl-CTLs. F(ab')2 and Fab alpha-CD2 produced inhibition similar to intact mAbs when added at the time of the lytic assay, whereas both produced only modest inhibition in vivo or when added at the initiation of culture. Alloantigen-specific CTLs were not affected by Ab addition to either culture or assay. The immunosuppressive effects were generalizable because a panel of alpha-CD2 mAbs were all comparably effective in suppressing hapten-specific CTLs when administered in vivo. The results demonstrate that the inhibitory effects are the result of blockade of receptor adhesion function during Ag priming or target recognition, Fc-related effects, and the generation of a negative regulatory, CD4+CD8-, IL-4- and TGF-beta-producing TH2 suppressor T cell.

  • Copyright © 1994 by American Association of Immunologists

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The Journal of Immunology
Vol. 152, Issue 8
15 Apr 1994
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Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade.
K D Chavin, L Qin, R Yon, J Lin, H Yagita, J S Bromberg
The Journal of Immunology April 15, 1994, 152 (8) 3729-3739;

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Anti-CD2 mAbs suppress cytotoxic lymphocyte activity by the generation of Th2 suppressor cells and receptor blockade.
K D Chavin, L Qin, R Yon, J Lin, H Yagita, J S Bromberg
The Journal of Immunology April 15, 1994, 152 (8) 3729-3739;
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Print ISSN 0022-1767        Online ISSN 1550-6606