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Production of minor lymphocyte stimulatory-1a antigen from activated CD4+ or CD8+ T cells.

N Arase-Fukushi, H Arase, K Ogasawara, R A Good and K Onoé
J Immunol November 1, 1993, 151 (9) 4445-4454;
N Arase-Fukushi
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H Arase
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K Ogasawara
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R A Good
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K Onoé
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Abstract

Minor lymphocyte stimulatory (Mls) Ag are super Ag that stimulate a high proportion of T cells of a specific TCR V beta family. One of the super Ag, Mls-1a, which is recognized mainly by TCR V beta 6+ and V beta 8.1+ T cells, has recently been linked to the response to product of the open reading frame in 3'-long terminal repeat of endogenous mammary tumor virus, MTV-7. It is quite certain that B cells are able to produce and also to present the Mls-1a Ag. However, it remains to be determined whether other cell types, especially T cells, produce Mls-1a Ag. In this study using highly purified T cell subpopulations, capacity to produce Mls-1a Ag was analyzed by calculating the proportion of Mls-1a reactive V beta 6+ or V beta 8.1+ T cells in responding cell populations. We found that nonstimulated CD8+ T cells produced a low amount of Mls-1a Ag, and the capacity to do so was considerably increased by stimulation with immobilized anti-TCR mAb. By contrast, nonstimulated CD4+ T cells did not produce Mls-1a Ag at all. Even when CD4+ T cells were activated via TCR signaling with immobilized anti-TCR mAb, CD4+ T cells did not produce Mls-1a Ag. However, CD4+ T cells primed with conventional Ag in vivo produced Mls-1a Ag on restimulation with that specific Ag in vitro. These findings indicate that not only CD8+ T cells but also CD4+ T cells can produce Mls-1a Ag on appropriate stimulation, although different mechanisms for Mls-1a production may operate between the CD4+ and CD8+ T cells.

  • Copyright © 1993 by American Association of Immunologists

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The Journal of Immunology
Vol. 151, Issue 9
1 Nov 1993
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Production of minor lymphocyte stimulatory-1a antigen from activated CD4+ or CD8+ T cells.
N Arase-Fukushi, H Arase, K Ogasawara, R A Good, K Onoé
The Journal of Immunology November 1, 1993, 151 (9) 4445-4454;

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Production of minor lymphocyte stimulatory-1a antigen from activated CD4+ or CD8+ T cells.
N Arase-Fukushi, H Arase, K Ogasawara, R A Good, K Onoé
The Journal of Immunology November 1, 1993, 151 (9) 4445-4454;
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Print ISSN 0022-1767        Online ISSN 1550-6606