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Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms.

T Uchiyama, T Miyoshi-Akiyama, H Kato, W Fujimaki, K Imanishi and X J Yan
J Immunol October 15, 1993, 151 (8) 4407-4413;
T Uchiyama
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T Miyoshi-Akiyama
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H Kato
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W Fujimaki
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K Imanishi
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X J Yan
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Abstract

A novel product from Yersinia pseudotuberculosis exhibiting mitogenic activity for human PBMC (designated Y. pseudotuberculosis-derived mitogen, YPM) was examined for its biologic activities for human lymphocytes. YPM induced a substantial proliferative response and IL-2 production at 0.1 ng/ml or more in whole PBMC but not in T-depleted PBMC. IL-2 production occurred within 12 h after YPM stimulation. T cells from PBMC produced IL-2 in the presence of L cells transfected with HLA DR genes or DP genes but not in the presence of control L cells used as accessory cells. Paraformaldehyde fixation did not abolish the AC activity of the DR+ L cells. The results suggest that YPM bind directly to HLA class II molecules. Analysis of the TCR V beta element using the polymerase chain reaction revealed that YPM selectively activated human T cells bearing V beta 3, V beta 9, V beta 13.1, and V beta 13.2 in TCR. These results indicate that YPM is a potent T cell activator and has superantigenic properties (abilities to bind directly to MHC class II molecules and selectively stimulate T cell populations bearing particular V beta elements in TCR). The role of YPM in the mechanism of pathogenesis of Y. pseudotuberculosis infections manifesting acute and systemic clinical symptoms is discussed.

  • Copyright © 1993 by American Association of Immunologists

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The Journal of Immunology
Vol. 151, Issue 8
15 Oct 1993
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Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms.
T Uchiyama, T Miyoshi-Akiyama, H Kato, W Fujimaki, K Imanishi, X J Yan
The Journal of Immunology October 15, 1993, 151 (8) 4407-4413;

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Superantigenic properties of a novel mitogenic substance produced by Yersinia pseudotuberculosis isolated from patients manifesting acute and systemic symptoms.
T Uchiyama, T Miyoshi-Akiyama, H Kato, W Fujimaki, K Imanishi, X J Yan
The Journal of Immunology October 15, 1993, 151 (8) 4407-4413;
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Print ISSN 0022-1767        Online ISSN 1550-6606