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Characterization of murine T cell responses to peptides of the variable region of self T cell receptor beta-chains.

D MacNeil, E Fraga and B Singh
J Immunol October 15, 1993, 151 (8) 4045-4054;
D MacNeil
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E Fraga
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B Singh
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Abstract

Immunization with peptides of the TCR may regulate cellular immune responses that are dominated by a particular TCR. However, no extensive study of the immunogenicity of peptides of different regions of the V beta chain of the TCR has been done. We have tested the immunogenicity of several V beta peptides in several strains of mice and characterized the cellular response to these peptides. We examined the ability of six strains of mice of H-2b, H-2d, or H-2k and of mouse lymphocyte stimulatory (Mls)-1a or Mls-1b haplotypes to respond to several peptides of the V beta 6 region and an NH2-terminal peptide of other V beta of the TCR. These include V beta 6 peptides 1-20, 32-48, 39-60, 48-75, 58-75, and V beta 3, V beta 8.1, and V beta 8.3 peptides 1-20. The various mouse strains respond to these peptides independently of deletion of V beta 6+ T cells from peripheral lymphocytes. All of the Mls deleting and nondeleting strains tested respond weakly to one peptide of V beta 6, V beta 6(39-60). Antibody titers were also demonstrated in BALB/c and DBA/2J to V beta 6(1-20), V beta 6(39-60) and V beta 6(48-75), but not to V beta 6(32-48). We demonstrated that T cells responding to V beta 6(32-48) produce IL-2 and IFN-gamma, consistent with the Th1 subset of T cells. None of the antipeptide antibodies recognized the intact V beta 6 TCR on the cell surface. In vitro antibody blocking studies with TCR peptides show that these peptides are presented by class II MHC to CD4+ T cells. We conclude that the T cell and B cell repertoires contain cells able to respond to peptides of self TCR and immunization with peptides induces CD4+ T cells and that these cells may have an immunoregulatory role.

  • Copyright © 1993 by American Association of Immunologists

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The Journal of Immunology
Vol. 151, Issue 8
15 Oct 1993
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Characterization of murine T cell responses to peptides of the variable region of self T cell receptor beta-chains.
D MacNeil, E Fraga, B Singh
The Journal of Immunology October 15, 1993, 151 (8) 4045-4054;

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Characterization of murine T cell responses to peptides of the variable region of self T cell receptor beta-chains.
D MacNeil, E Fraga, B Singh
The Journal of Immunology October 15, 1993, 151 (8) 4045-4054;
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Print ISSN 0022-1767        Online ISSN 1550-6606