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Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.

I Stancovski, D G Schindler, T Waks, Y Yarden, M Sela and Z Eshhar
J Immunol December 1, 1993, 151 (11) 6577-6582;
I Stancovski
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D G Schindler
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T Waks
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Y Yarden
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M Sela
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Z Eshhar
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Abstract

Cell surface molecules essential for the transformed phenotype or growth of malignant cells are attractive targets for anticancer immunotherapy. Antibodies specific to Neu/HER2, a human adenocarcinoma-associated growth factor receptor, were demonstrated to have tumor-inhibitory capacity. Yet, the inefficient accessibility of antibodies to solid tumors limits their clinical use. To redirect effector lymphocytes to adenocarcinomas, we constructed and functionally expressed in T cells chimeric single chain receptor genes incorporating both the Ag-binding domain of anti-Neu/HER2 antibodies and the zeta-signal-transducing subunit of the TCR/CD3 complex or the gamma-signal-transducing subunit of the Ig Fc receptor complex. Surface expression of the anti-Neu/HER2 chimeric genes in cytotoxic T cell hybridomas endowed them with specific Neu/HER2 recognition enabling their activation for IL-2 production and lysis of transformed cells overexpressing Neu/HER2. These chimeric genes hold promise for the immunotherapy of cancer.

  • Copyright © 1993 by American Association of Immunologists
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The Journal of Immunology
Vol. 151, Issue 11
1 Dec 1993
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Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.
I Stancovski, D G Schindler, T Waks, Y Yarden, M Sela, Z Eshhar
The Journal of Immunology December 1, 1993, 151 (11) 6577-6582;

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Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors.
I Stancovski, D G Schindler, T Waks, Y Yarden, M Sela, Z Eshhar
The Journal of Immunology December 1, 1993, 151 (11) 6577-6582;
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Print ISSN 0022-1767        Online ISSN 1550-6606