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Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.

H Nagafuchi, N Suzuki, Y Mizushima and T Sakane
J Immunol December 1, 1993, 151 (11) 6525-6534;
H Nagafuchi
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N Suzuki
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Y Mizushima
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T Sakane
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Abstract

Excessive B cell function including autoantibody production is a common feature of SLE and considered to be intimately associated with spontaneous lymphokine secretion by themselves. To clarify roles of IL-6/IL-6 receptor autocrine activation pathway in autoantibody production observed in patients with SLE, we studied expression and function of IL-6 receptors in comparison with those of IL-2 receptors, Tac on SLE B cells. IL-6 receptors and IL-2 receptors have been detected on B cells in the blood without any in vitro stimuli in most patients with SLE. The introduction of anti-IL-6 receptor antibody, which inhibits binding to the receptors of IL-6, and anti-IL-2 receptor antibody, anti-Tac to the cultures of SLE B cells resulted in potent inhibition of spontaneous production of polyclonal Ig and anti-DNA autoantibodies. In addition, fresh SLE B cells secreted high levels of IL-6 without any in vitro stimuli. These results indicate that constitutive expression of IL-6 receptors on B cells in conjunction with spontaneous IL-6 production by B cells induces autocrine B cell activation, which may lead to B cell hyperactivity and autoantibody secretion in SLE patients. Dysregulation of B cell activity observed in patients with SLE could thus be, at least in part, independent of T cell help.

  • Copyright © 1993 by American Association of Immunologists

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The Journal of Immunology
Vol. 151, Issue 11
1 Dec 1993
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Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.
H Nagafuchi, N Suzuki, Y Mizushima, T Sakane
The Journal of Immunology December 1, 1993, 151 (11) 6525-6534;

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Constitutive expression of IL-6 receptors and their role in the excessive B cell function in patients with systemic lupus erythematosus.
H Nagafuchi, N Suzuki, Y Mizushima, T Sakane
The Journal of Immunology December 1, 1993, 151 (11) 6525-6534;
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Print ISSN 0022-1767        Online ISSN 1550-6606