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Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.

Y Ito, M Nieda, Y Uchigata, M Nishimura, K Tokunaga, S Kuwata, F Obata, K Tadokoro, Y Hirata and Y Omori
J Immunol November 15, 1993, 151 (10) 5770-5776;
Y Ito
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M Nieda
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Y Uchigata
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M Nishimura
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K Tokunaga
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S Kuwata
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F Obata
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K Tadokoro
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Y Hirata
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Y Omori
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Abstract

Our recent study indicated that all the insulin autoimmune syndrome (IAS) patients had specific HLA class II alleles, the DRB1*0406, DQA1*0301, and DQB1*0302, which allowed T cells to proliferate when autologous APC were exposed to human insulin. The study implied that gene products of DRB1*0406, DQA1*0301, and/or DQB1*0302 may be involved in the presentation of human insulin to T cells. We therefore examined T cell response of healthy donors with different HLA phenotypes to human insulin using an autologous MLR system. The T cells from not only IAS patients but also healthy donors were able to proliferate after exposure of human insulin to autologous APC with DRB1*0406, DQA1*0301, and DQB1*0302 products. The class II molecules are considered to be involved in the recognition of human insulin by T cells. The proliferative response of T cells was completely blocked by anti-HLA-DR mAb and not by anti-HLA-DQ mAb or other mAb. Furthermore, human insulin-specific CD4-positive T cell clones were established from blast cells in autologous MLR of PBMC from two healthy donors with DRB1*0406 in the presence of human insulin. Using DRB1*0406-transfected L cells as APC, we confirmed that these T cells clones recognize human insulin in the context of gene products of DRB1*0406. These results provide the first evidence that HLA-DRB1*0406 products act as the dominant restriction element for the presentation of human insulin to T cells, and suggest that this particular class II gene, HLA-DRB1*0406, contributes to the development of IAS.

  • Copyright © 1993 by American Association of Immunologists

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The Journal of Immunology
Vol. 151, Issue 10
15 Nov 1993
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Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.
Y Ito, M Nieda, Y Uchigata, M Nishimura, K Tokunaga, S Kuwata, F Obata, K Tadokoro, Y Hirata, Y Omori
The Journal of Immunology November 15, 1993, 151 (10) 5770-5776;

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Recognition of human insulin in the context of HLA-DRB1*0406 products by T cells of insulin autoimmune syndrome patients and healthy donors.
Y Ito, M Nieda, Y Uchigata, M Nishimura, K Tokunaga, S Kuwata, F Obata, K Tadokoro, Y Hirata, Y Omori
The Journal of Immunology November 15, 1993, 151 (10) 5770-5776;
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Print ISSN 0022-1767        Online ISSN 1550-6606