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IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite.

S Pied, A Civas, F Berlot-Picard, L Renia, F Miltgen, M Gentilini, J Doly and D Mazier
J Immunol January 1, 1992, 148 (1) 197-201;
S Pied
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A Civas
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F Berlot-Picard
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L Renia
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F Miltgen
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M Gentilini
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J Doly
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D Mazier
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Abstract

The capacity of IL-6 to mediate the antiparasitic activity of IL-1 on intrahepatic development of malaria parasite was demonstrated. The comparisons of IL-6 levels in infected and noninfected hepatocyte cultures, either purified or enriched with nonparenchymal cells and stimulated by IL-1 or IL-6, indicate that subtle interactions exist between intrahepatocytic development of Plasmodium yoelii and liver synthesis of IL-6. During its intrahepatic multiplication, the parasite causes a decline in IL-6 production. IL-6 mRNA was not detected in the livers of infected mice during development of either hepatic or blood stage parasites although IL-6 activity was found in the sera during both stages.

  • Copyright © 1992 by American Association of Immunologists
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The Journal of Immunology
Vol. 148, Issue 1
1 Jan 1992
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IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite.
S Pied, A Civas, F Berlot-Picard, L Renia, F Miltgen, M Gentilini, J Doly, D Mazier
The Journal of Immunology January 1, 1992, 148 (1) 197-201;

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IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite.
S Pied, A Civas, F Berlot-Picard, L Renia, F Miltgen, M Gentilini, J Doly, D Mazier
The Journal of Immunology January 1, 1992, 148 (1) 197-201;
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Print ISSN 0022-1767        Online ISSN 1550-6606